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Flommersfeld, Sabine; Sohlbach, Kristina; Jaques, Gabriele; Bein, Gregor; Hoffmann, Jörg; Kostrewa, Philippe; Sachs, Ulrich J.

Collection of peripheral blood progenitor cells on Day 4 is feasible and effective while reducing granulocyte–colony‐stimulating factor exposure to healthy donors

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  • Medientyp: E-Artikel
  • Titel: Collection of peripheral blood progenitor cells on Day 4 is feasible and effective while reducing granulocyte–colony‐stimulating factor exposure to healthy donors
  • Beteiligte: Flommersfeld, Sabine; Sohlbach, Kristina; Jaques, Gabriele; Bein, Gregor; Hoffmann, Jörg; Kostrewa, Philippe; Sachs, Ulrich J.
  • Erschienen: Wiley, 2015
  • Erschienen in: Transfusion, 55 (2015) 6, Seite 1269-1274
  • Sprache: Englisch
  • DOI: 10.1111/trf.13002
  • ISSN: 0041-1132; 1537-2995
  • Schlagwörter: Hematology ; Immunology ; Immunology and Allergy
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>BACKGROUND</jats:title><jats:p>Peripheral blood progenitor cells (PBPCs) are the most common stem cell source for allogeneic transplantations. Analysis of our collection data obtained with a Spectra Optia device (Terumo) for apheresis demonstrated collection efficacies (CEs) exceeding our internal target levels of 5 × 10<jats:sup>6</jats:sup> CD34+ cells/kg body weight of the recipient when collected on Day 5. We thus aimed to investigate whether collection on Day 4 would lead to adequate amounts of PBPCs while minimizing granulocyte–colony‐stimulating factor (G‐CSF) exposure in healthy donors.</jats:p></jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS</jats:title><jats:p>We compared feasibility and effectiveness of Day 5 versus Day 4 collections with data obtained from 23 and 18 allogeneic procedures, respectively.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Both groups were comparable with regard to donor and collection characteristics. Product characteristics as well as platelet loss, CE, throughput, and collection rate did not differ between both protocols. A higher contamination with white blood cells (WBCs; ×10<jats:sup>9</jats:sup>/L) was observed in products collected on Day 5 compared to Day 4 (231 [range, 181‐299] vs. 203 [range, 165‐239]; p = 0.004). A second apheresis procedure was required in three of 23 patients and three of 18 patients, respectively (p = 0.6) to obtain the required PBPC dose.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>PBPC apheresis on Day 4 seems as feasible and effective as collection on Day 5. Collection on Day 4 produces lower WBC content in the product and allows a reduction in G‐CSF exposure to healthy donors.</jats:p></jats:sec>