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Medientyp:
E-Artikel
Titel:
Protein restriction cycles reduce IGF‐1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model
Beteiligte:
Parrella, Edoardo;
Maxim, Tom;
Maialetti, Francesca;
Zhang, Lu;
Wan, Junxiang;
Wei, Min;
Cohen, Pinchas;
Fontana, Luigi;
Longo, Valter D.
Erschienen:
Wiley, 2013
Erschienen in:Aging Cell
Sprache:
Englisch
DOI:
10.1111/acel.12049
ISSN:
1474-9718;
1474-9726
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Summary</jats:title><jats:p>In laboratory animals, calorie restriction (<jats:styled-content style="fixed-case">CR</jats:styled-content>) protects against aging, oxidative stress, and neurodegenerative pathologies. Reduced levels of growth hormone and <jats:styled-content style="fixed-case">IGF</jats:styled-content>‐1, which mediate some of the protective effects of <jats:styled-content style="fixed-case">CR</jats:styled-content>, can also extend longevity and/or protect against age‐related diseases in rodents and humans. However, severely restricted diets are difficult to maintain and are associated with chronically low weight and other major side effects. Here we show that 4 months of periodic protein restriction cycles (<jats:styled-content style="fixed-case">PRC</jats:styled-content>s) with supplementation of nonessential amino acids in mice already displaying significant cognitive impairment and Alzheimer's disease (<jats:styled-content style="fixed-case">AD</jats:styled-content>)‐like pathology reduced circulating <jats:styled-content style="fixed-case">IGF</jats:styled-content>‐1 levels by 30–70% and caused an 8‐fold increase in <jats:styled-content style="fixed-case">IGFBP</jats:styled-content>‐1. Whereas <jats:styled-content style="fixed-case">PRC</jats:styled-content>s did not affect the levels of β amyloid (Aβ), they decreased tau phosphorylation in the hippocampus and alleviated the age‐dependent impairment in cognitive performance. These results indicate that periodic protein restriction cycles without <jats:styled-content style="fixed-case">CR</jats:styled-content> can promote changes in circulating growth factors and tau phosphorylation associated with protection against age‐related neuropathologies.</jats:p>