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Lorentzen, Thomas Dam; Subhi, Yousif; Sørensen, Torben Lykke

Presenting characteristics and prevalence of polypoidal choroidal vasculopathy in Scandinavian patients with treatment‐naïve exudative age‐related macular degeneration

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  • Medientyp: E-Artikel
  • Titel: Presenting characteristics and prevalence of polypoidal choroidal vasculopathy in Scandinavian patients with treatment‐naïve exudative age‐related macular degeneration
  • Beteiligte: Lorentzen, Thomas Dam; Subhi, Yousif; Sørensen, Torben Lykke
  • Erschienen: Wiley, 2018
  • Erschienen in: Acta Ophthalmologica
  • Sprache: Englisch
  • DOI: 10.1111/aos.13646
  • ISSN: 1755-375X; 1755-3768
  • Schlagwörter: Ophthalmology ; General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Purpose</jats:title><jats:p>To study presenting characteristics and prevalence of polypoidal choroidal vasculopathy (<jats:styled-content style="fixed-case">PCV</jats:styled-content>) in Scandinavian Caucasians with treatment‐naïve exudative age‐related macular degeneration (<jats:styled-content style="fixed-case">AMD</jats:styled-content>).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We reviewed all patients referred in year 2014 and diagnosed using fundus examination, optical coherence tomography, and fluorescein and indocyanine green angiography (ICGA). Details of found <jats:styled-content style="fixed-case">PCV</jats:styled-content>s and its subtypes (clinical and angiographical) were correlated to the baseline best‐corrected visual acuity (<jats:styled-content style="fixed-case">BCVA</jats:styled-content>).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 299 Caucasian patients with a tentative diagnosis of exudative <jats:styled-content style="fixed-case">AMD</jats:styled-content>, 18 eyes of 17 patients (5.7%, <jats:styled-content style="fixed-case">CI</jats:styled-content> 95%: 3.5–9.1%) had <jats:styled-content style="fixed-case">PCV</jats:styled-content>. Patients with <jats:styled-content style="fixed-case">PCV</jats:styled-content> were 75.8 (<jats:styled-content style="fixed-case">SD</jats:styled-content>: 7.5) years old and 11 (65%) were females. Lesions were predominantly extramacular. Most eyes (56%) had subretinal haemorrhage, 39% had the exudative type and one (6%) eye had the quiescent type. Larger lesion area and disruption of the foveal inner‐segment/outer‐segment layer correlated with worse baseline <jats:styled-content style="fixed-case">BCVA</jats:styled-content>. Polypoidal choroidal vasculopathy (<jats:styled-content style="fixed-case">PCV</jats:styled-content>) type 1 was present in 50% and <jats:styled-content style="fixed-case">PCV</jats:styled-content> type 2 in the other 50%. Polypoidal choroidal vasculopathy (<jats:styled-content style="fixed-case">PCV</jats:styled-content>) type 1 was associated with a worse baseline <jats:styled-content style="fixed-case">BCVA</jats:styled-content> and greater lesion size.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Polypoidal choroidal vasculopathy (<jats:styled-content style="fixed-case">PCV</jats:styled-content>) is not a rare condition in Danes with exudative <jats:styled-content style="fixed-case">AMD</jats:styled-content> and presents often extramacular and with haemorrhage. This study underscores the importance of ICGA as a part of the diagnostic repertoire in <jats:styled-content style="fixed-case">AMD</jats:styled-content> and suggests its routine use in Scandinavian populations.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang