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Kocatürk, Emek; Al‐Ahmad, Mona; Krause, Karoline; Gimenez‐Arnau, Ana M.; Thomsen, Simon Francis; Conlon, Niall; Marsland, Alexander; Savk, Ekin; Criado, Roberta F.; Danilycheva, Inna; Fomina, Daria; Godse, Kiran; Khoshkhui, Maryam; Gelincik, Aslı; Degirmentepe, Ece Nur; Demir, Semra; Ensina, Luis Felipe; Kasperska‐Zajac, Alicja; Rudenko, Michael; Valle, Solange; Medina, Iris; Bauer, Andrea; Zhao, Zuotao; Staubach, Petra; [...]

Effects of pregnancy on chronic urticaria: Results of the PREG‐CU UCARE study

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  • Medientyp: E-Artikel
  • Titel: Effects of pregnancy on chronic urticaria: Results of the PREG‐CU UCARE study
  • Beteiligte: Kocatürk, Emek; Al‐Ahmad, Mona; Krause, Karoline; Gimenez‐Arnau, Ana M.; Thomsen, Simon Francis; Conlon, Niall; Marsland, Alexander; Savk, Ekin; Criado, Roberta F.; Danilycheva, Inna; Fomina, Daria; Godse, Kiran; Khoshkhui, Maryam; Gelincik, Aslı; Degirmentepe, Ece Nur; Demir, Semra; Ensina, Luis Felipe; Kasperska‐Zajac, Alicja; Rudenko, Michael; Valle, Solange; Medina, Iris; Bauer, Andrea; Zhao, Zuotao; Staubach, Petra; [...]
  • Erschienen: Wiley, 2021
  • Erschienen in: Allergy
  • Sprache: Englisch
  • DOI: 10.1111/all.14950
  • ISSN: 0105-4538; 1398-9995
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Chronic urticaria (CU) predominantly affects women, and sex hormones can modulate disease activity in female CU patients. As of now, the impact of pregnancy on CU is largely unknown.</jats:p></jats:sec><jats:sec><jats:title>Aim</jats:title><jats:p>To analyze the course and features of CU during and after pregnancy.</jats:p></jats:sec><jats:sec><jats:title>Patients and methods</jats:title><jats:p>PREG‐CU is an international, multicenter study of the Urticaria Centers of Reference and Excellence (UCARE) network. Data were collected via a 47‐item questionnaire completed by CU patients, who became pregnant within the last 3 years.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 288 pregnancies of 288 CU patients from 13 countries were analyzed (mean age at pregnancy: 32.1 ± 6.1 years, duration of CU: 84.9 ± 74.5 months; CSU 66.9%, CSU + CIndU 20.3%, CIndU 12.8%).During pregnancy, 51.1% of patients rated their CU as improved, 28.9% as worse, and 20.0% as unchanged.CU exacerbations most commonly occurred exclusively during the third trimester (in 34 of 124 patients; 27.6%) or the first (28 of 124; 22.8%). The risk factors for worsening of CU during pregnancy were having mild disease and no angioedema before pregnancy, not taking treatment before pregnancy, CIndU, CU worsening during a previous pregnancy, treatment during pregnancy, and stress as a driver of exacerbations. After giving birth, urticaria disease activity remained unchanged in 43.8% of CU patients, whereas 37.4% and 18.1% experienced worsening and improvement, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These results demonstrate the complex impact of pregnancy on the course of CU and help to better counsel patients who want to become pregnant and to manage CU during pregnancy.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang