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Fredman, Gabriella; Kolpen, Mette; Hertz, Frederik Boetius; Petersen, Pelle Trier; Jensen, Andreas Vestergaard; Baunbæk‐Egelund, Gertrud; Ravn, Pernille; Jensen, Peter Østrup; Faurholt‐Jepsen, Daniel

The inflamed sputum in lower respiratory tract infection: l‐lactate levels are correlated to neutrophil accumulation

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  • Medientyp: E-Artikel
  • Titel: The inflamed sputum in lower respiratory tract infection: l‐lactate levels are correlated to neutrophil accumulation
  • Beteiligte: Fredman, Gabriella; Kolpen, Mette; Hertz, Frederik Boetius; Petersen, Pelle Trier; Jensen, Andreas Vestergaard; Baunbæk‐Egelund, Gertrud; Ravn, Pernille; Jensen, Peter Østrup; Faurholt‐Jepsen, Daniel
  • Erschienen: Wiley, 2019
  • Erschienen in: APMIS, 127 (2019) 2, Seite 72-79
  • Sprache: Englisch
  • DOI: 10.1111/apm.12913
  • ISSN: 0903-4641; 1600-0463
  • Schlagwörter: Microbiology (medical) ; General Medicine ; Immunology and Allergy ; Pathology and Forensic Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:label /><jats:p>Lower respiratory tract infections (<jats:styled-content style="fixed-case">LRTI</jats:styled-content>) are common, but little is known about the response of biomarkers of inflammation in the lungs. Therefore, our primary aim was to compare the concentration of <jats:sc>l</jats:sc>‐lactate to the concentration of neutrophils in sputum and systemic markers of infection. Because it is difficult to differentiate viral and bacterial infection on the basis of clinical presentation in LRTI, our secondary aim was to evaluate if <jats:sc>l</jats:sc>‐ and <jats:sc>d</jats:sc>‐lactate may serve as markers of local inflammation as representatives of neutrophils and bacteria, respectively.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients with acute <jats:styled-content style="fixed-case">LRTI</jats:styled-content> were prospectively recruited. Sputum samples were collected and analysed for neutrophil count, <jats:sc>l</jats:sc>‐lactate and <jats:sc>d</jats:sc>‐lactate. We had data on pathogens from sputum cultures and polymerase chain reaction (<jats:styled-content style="fixed-case">PCR</jats:styled-content>) (atypical bacteria, virus) and C‐reactive protein (<jats:styled-content style="fixed-case">CRP</jats:styled-content>) from blood.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In 44 sputum samples from 32 patients, the median (interquartile range (<jats:styled-content style="fixed-case">IQR</jats:styled-content>)) sputum neutrophil granulocyte count was 0.615 × 10<jats:sup>7</jats:sup> cells/mL (0.236–1.575). The sputum neutrophil granulocyte count was associated with sputum <jats:sc>l</jats:sc>‐lactate (p = 0.011) and <jats:styled-content style="fixed-case">CRP</jats:styled-content> (p = 0.018), but not with <jats:sc>d</jats:sc>‐lactate (p = 0.177). There was a strong association between sputum <jats:sc>d</jats:sc>‐lactate and <jats:sc>l</jats:sc>‐lactate (p &lt; 0.0001).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>As <jats:sc>l</jats:sc>‐lactate in sputum is closely correlated to sequestration of neutrophils in the lungs, <jats:sc>l</jats:sc>‐lactate is a marker for local inflammation in <jats:styled-content style="fixed-case">LRTI</jats:styled-content> and a potential biomarker in clinical management of <jats:styled-content style="fixed-case">LRTI</jats:styled-content>. On expectorated sputum, <jats:sc>d</jats:sc>‐lactate had no clinical relevance.</jats:p></jats:sec>