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Medientyp:
E-Artikel
Titel:
Bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN): a part of osteomyelitis disease biology
Beteiligte:
Jensen, Louise Kruse;
Birch, Julie Melsted;
Jensen, Henrik Elvang;
Kirketerp‐Møller, Klaus;
Gottlieb, Hans
Erschienen:
Wiley, 2023
Erschienen in:
APMIS, 131 (2023) 7, Seite 325-332
Sprache:
Englisch
DOI:
10.1111/apm.13312
ISSN:
0903-4641;
1600-0463
Entstehung:
Anmerkungen:
Beschreibung:
Two chronic osteomyelitis patients, a diabetic foot osteomyelitis patient and a fracture‐related infection patient, all with staphylococci‐positive microbiology, were examined to confirm the clinical relevance of bacterial invasion of the submicron osteocyte lacuna–canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry and light microscopy both Staphylococcus aureus and Staphylococcus epidermidis were identified within the OLCN of all four patients. The findings consolidate that bacterial OLCN invasion is a clinically relevant part of osteomyelitis disease biology, which from experimental porcine infections, seems to be time depending. The microscopy pictures of the four patients significantly add to visualize the phenomenon of bacterial OLCN invasion.