Beschreibung:
Bis (histidine) ethylenediamine tetraacetic acid, EDTA‐bis (amide) analog, has been synthesized starting from with EDTA bis‐anhydride and protected histidine and evaluated in vitro as an important agent for MR and chelation therapy. The kinetic inertness of compound was analyzed by the exchange reactions with the essential metals of human body. The stability and protonation constants of the complexes formed between the ligand and M3+ and M2+ have been determined by pH potentiometry and spectrophotometry at 25 °C and constant ionic strength maintained with 0.10 m KCl. The in vivo stability and metabolite profile were confirmed in plasma and serum.