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Tanriver, Ursula; Emmerich, Florian; Hummel, Jonas Florian; Jänigen, Bernd; Panning, Marcus; Arnold, Frederic; Tanriver, Yakup

IFNL4 rs368234815 polymorphism does not predict risk of BK virus associated nephropathy after living‐donor kidney transplant: A case‐control study

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  • Medientyp: E-Artikel
  • Titel: IFNL4 rs368234815 polymorphism does not predict risk of BK virus associated nephropathy after living‐donor kidney transplant: A case‐control study
  • Beteiligte: Tanriver, Ursula; Emmerich, Florian; Hummel, Jonas Florian; Jänigen, Bernd; Panning, Marcus; Arnold, Frederic; Tanriver, Yakup
  • Erschienen: Wiley, 2022
  • Erschienen in: Clinical Transplantation, 36 (2022) 7
  • Sprache: Englisch
  • DOI: 10.1111/ctr.14663
  • ISSN: 0902-0063; 1399-0012
  • Schlagwörter: Transplantation
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>BK polyoma virus (BKPyV) associated nephropathy (BKPyVAN) is a major cause of kidney graft loss in renal transplant patients. Interferons (IFNs) are an important innate immune response against viral infections and genetic polymorphisms of the IFN‐pathways can affect susceptibility and mortality during viral infection. Here, we investigated whether the dinucleotide polymorphism rs368234815 (ΔG/TT) in the <jats:italic>IFNL4</jats:italic> gene contributed to BKPyV reactivation or BKPyVAN after living‐donor kidney transplantation.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This retrospective case‐control study determines the prevalence of <jats:italic>IFNL4</jats:italic> variants in a Caucasian population of living‐donor kidney transplant recipients and donors and explores its association with BKPyV infection and BKPyVAN development. We included 28 recipients with BKPyV reactivation, 10 of which developed BKPyVAN and 30 BKPyV negative controls. Targeted sequencing of the <jats:italic>IFNL4</jats:italic> gene from both recipients and their respective donors was performed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We found <jats:italic>IFNL4</jats:italic> rs368234815 ΔG allele frequencies of 41.7% in BKPyV negative and 39.3% in BKPyV positive recipients (<jats:italic>P</jats:italic> = .85), and 41.7% and 40.4% (<jats:italic>P</jats:italic>&gt;.99) in their respective donors. <jats:italic>IFNL4</jats:italic> rs368234815 ΔG allele frequencies in BKPyVAN developing recipients and their respective donors were 50% and 43.7% (<jats:italic>P</jats:italic> = .60 and <jats:italic>P</jats:italic>&gt;.99).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our results indicate that the <jats:italic>IFNL4</jats:italic> rs368234815 ΔG allele is not associated with BKPyV reactivation, nor the manifestation of BKPyVAN.</jats:p></jats:sec>