Beschreibung:
<jats:p>No clinical studies on the lipolytic effect of guanine nucleotide‐binding protein β3 subunit gene (<jats:italic><jats:styled-content style="fixed-case">GNB3</jats:styled-content></jats:italic>) <jats:styled-content style="fixed-case">825T</jats:styled-content> polymorphism have been performed. This study was a subinvestigation of a 12‐week randomized controlled trial (<jats:styled-content style="fixed-case">NCT01184560</jats:styled-content>) for the additive effect of orlistat on sibutramine treatment. The analysis involved 101 obese females aged 18–49 years, genotyped at the <jats:italic><jats:styled-content style="fixed-case">GNB3</jats:styled-content></jats:italic> 825 locus. To exclude any influence from potential confounders, we used an analysis of covariance model. After the intervention, fat mass proportion in total weight loss was significantly lower in subjects with a T allele than in those without a T allele (p = 0.034). <jats:italic><jats:styled-content style="fixed-case">GNB3</jats:styled-content></jats:italic> <jats:styled-content style="fixed-case">825T</jats:styled-content> allele was associated with blunted fat mass reduction in obese females.</jats:p>