Santos‐Lozano, José M.;
Rada, Mirela;
Lapetra, José;
Guinda, Ángeles;
Jiménez‐Rodríguez, María C.;
Cayuela, José A.;
Ángel‐Lugo, Antonio;
Vilches‐Arenas, Ángel;
Gómez‐Martín, Ana M.;
Ortega‐Calvo, Manuel;
Castellano, José M.
Prevention of type 2 diabetes in prediabetic patients by using functional olive oil enriched in oleanolic acid: The PREDIABOLE study, a randomized controlled trial
Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Prevention of type 2 diabetes in prediabetic patients by using functional olive oil enriched in oleanolic acid: The PREDIABOLE study, a randomized controlled trial
Beteiligte:
Santos‐Lozano, José M.;
Rada, Mirela;
Lapetra, José;
Guinda, Ángeles;
Jiménez‐Rodríguez, María C.;
Cayuela, José A.;
Ángel‐Lugo, Antonio;
Vilches‐Arenas, Ángel;
Gómez‐Martín, Ana M.;
Ortega‐Calvo, Manuel;
Castellano, José M.
Erschienen:
Wiley, 2019
Erschienen in:
Diabetes, Obesity and Metabolism, 21 (2019) 11, Seite 2526-2534
Sprache:
Englisch
DOI:
10.1111/dom.13838
ISSN:
1462-8902;
1463-1326
Entstehung:
Anmerkungen:
Beschreibung:
AbstractAimTo assess whether the regular intake of an oleanolic acid (OA)‐enriched olive oil is effective in the prevention of diabetes.MethodsIn the PREDIABOLE study, prediabetic individuals (impaired fasting glucose and impaired glucose tolerance) of both sexes (176 patients, aged 30‐80 years) were randomized to receive 55 mL/day of OA‐enriched olive oil (equivalent dose 30 mg OA/day) [intervention group (IG)] or the same oil not enriched [control group (CG)]. The main outcome was the incidence of new‐onset type 2 diabetes in both groups.ResultsForty‐eight new diabetes cases occurred, 31 in the CG and 17 in the IG. The multivariate‐adjusted hazard ratio was 0.45 (95% CI, 0.24‐0.83) for the IG compared with the CG. Intervention‐related adverse effects were not reported.ConclusionsThe intake of OA‐enriched olive oil reduces the risk of developing diabetes in prediabetic patients. The results of the PREDIABOLE study promote the use of OA in new functional foods and drugs for the prevention of diabetes in individuals at risk of developing it.