Beschreibung:
<jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Current smokers in the general population have a lower 2 h plasma glucose after an oral glucose tolerance test (<jats:styled-content style="fixed-case">OGTT</jats:styled-content>) and a higher HbA<jats:sub>1c</jats:sub> than non‐smokers, but the relationships between <jats:styled-content style="fixed-case">OGTT</jats:styled-content>/HbA<jats:sub>1c</jats:sub> and smoking status have not been addressed in pregnancy. We analysed glycaemic measurements in women with gestational diabetes mellitus in relation to smoking status.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a review of the prospectively collected database of the diabetes and pregnancy clinic. We included women with gestational diabetes mellitus and a singleton pregnancy who delivered between 1986 and 2006. Bivariate and multivariate analyses were used to evaluate patient characteristics in relation to smoking status.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 2361 women met the inclusion criteria: 556 (23.5%) were active smokers, 266 (11.3%) quit during pregnancy and 1539 (65.2%) were non‐smokers. Most baseline characteristics were similar across groups. Diagnostic <jats:styled-content style="fixed-case">OGTT</jats:styled-content> was performed at a gestational age of [median (25th, 75<jats:sup>th</jats:sup> centiles)] 29 weeks (26, 33). Women who smoked at the beginning of pregnancy had a higher 1‐h plasma glucose than non‐smokers [11.8 (11, 12.7), 11.6 (11, 12.6) and 11.5 (10.8, 12.5) mmol/l, for active smokers, those who quit during pregnancy and non‐smokers, respectively, <jats:italic>P</jats:italic> < 0.001] and a lower 3‐h plasma glucose [7.3 (5.9, 8.4), 7.6 (6.4, 8.7) and 8.0 (6.8, 9.0) mmol/l, respectively, <jats:italic>P</jats:italic> < 0.001]. HbA<jats:sub>1c</jats:sub> was higher in women who smoked at the beginning of pregnancy. Multiple regression analysis confirmed the independent association of smoking status with HbA<jats:sub>1c</jats:sub> and <jats:styled-content style="fixed-case">OGTT</jats:styled-content> plasma glucose.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In women with gestational diabetes mellitus who smoke at the beginning of pregnancy, the shape of the <jats:styled-content style="fixed-case">OGTT</jats:styled-content> is consistent with accelerated glucose absorption, and HbA<jats:sub>1c</jats:sub> is higher than expected for glycaemic values.</jats:p></jats:sec>