Beschreibung:
<jats:sec><jats:title>Background</jats:title><jats:p>Patients with diabetes mellitus (<jats:styled-content style="fixed-case">DM</jats:styled-content>) are at high risk of left ventricular (<jats:styled-content style="fixed-case">LV</jats:styled-content>) dysfunction. A reduction of coronary flow reserve (<jats:styled-content style="fixed-case">CFR</jats:styled-content>) has been demonstrated in diabetic patients without coronary artery stenosis. In this study, we investigated the association between <jats:styled-content style="fixed-case">LV</jats:styled-content> myocardial diastolic and systolic functions and the <jats:styled-content style="fixed-case">CFR</jats:styled-content> in newly diagnosed diabetic patients in the absence of coronary artery disease.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>We studied 88 patients (mean age 49 ± 10 years) with newly diagnosed <jats:styled-content style="fixed-case">DM</jats:styled-content> and 40 healthy control subjects (mean age 50 ± 9 years). All subjects underwent transthoracic echocardiography. The myocardial performance index (<jats:styled-content style="fixed-case">MPI</jats:styled-content>) was determined by using pulsed‐wave Doppler. The <jats:styled-content style="fixed-case">CFR</jats:styled-content> was calculated as the hyperemic to resting coronary diastolic peak velocities ratio.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Patients with diabetes had significantly longer mitral E‐wave deceleration time and higher <jats:styled-content style="fixed-case">MPI</jats:styled-content> value than control group (P = 0.023 and P < 0.001, respectively). The mean <jats:styled-content style="fixed-case">CFR</jats:styled-content> was lower in diabetic patients compared with controls (P = 0.001). The <jats:styled-content style="fixed-case">MPI</jats:styled-content> was significantly correlated with <jats:styled-content style="fixed-case">CFR</jats:styled-content> (r = −0.371, P < 0.001), <jats:styled-content style="fixed-case">LV</jats:styled-content> ejection fraction (r = −0.274, P = 0.018) E/A ratio (r = −0.244, P = 0.024), and glycosylated hemoglobin (HbA1c) (r = 0.476, P < 0.001). Multivariate regression analysis showed that <jats:styled-content style="fixed-case">MPI</jats:styled-content> was independently associated with <jats:styled-content style="fixed-case">CFR</jats:styled-content> (β = −0.292, P < 0.0001) and HbA1c level (β = 0.372, P < 0.0001).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The <jats:styled-content style="fixed-case">MPI</jats:styled-content> was independently associated with <jats:styled-content style="fixed-case">CFR</jats:styled-content> in newly diagnosed diabetic patients. The decrease in <jats:styled-content style="fixed-case">CFR</jats:styled-content> may cause <jats:styled-content style="fixed-case">LV</jats:styled-content> systolic and diastolic dysfunction in asymptomatic diabetic patients.</jats:p></jats:sec>