Beschreibung:
<jats:sec><jats:title>Purpose</jats:title><jats:p>Myocardial strain and strain rate (<jats:styled-content style="fixed-case">SR</jats:styled-content>) can be derived from either tissue Doppler (<jats:styled-content style="fixed-case">TDI</jats:styled-content>) information or two‐dimensional speckle tracking. As conventional <jats:styled-content style="fixed-case">TDI</jats:styled-content> analysis (<jats:styled-content style="fixed-case">TDI</jats:styled-content>‐manual) is time‐consuming with poor reproducibility, we developed a faster semiautomated approach (<jats:styled-content style="fixed-case">TDI</jats:styled-content>‐<jats:styled-content style="fixed-case">ST</jats:styled-content>). We aimed to study the comparability of <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐<jats:styled-content style="fixed-case">ST</jats:styled-content> with <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐manual, an established method for measuring strain and <jats:styled-content style="fixed-case">SR</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Forty healthy subjects (mean age 38.3 ± 12.8 years) and 16 patients with <jats:styled-content style="fixed-case">FHL</jats:styled-content>‐1 cardiomyopathy (<jats:styled-content style="fixed-case">CMP</jats:styled-content>) (36.8 ± 14.2 years) were analyzed with <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐manual and <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐<jats:styled-content style="fixed-case">ST</jats:styled-content>. <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐<jats:styled-content style="fixed-case">ST</jats:styled-content> was performed with commercial software, using speckle tracking for myocardial tracking and <jats:styled-content style="fixed-case">TDI</jats:styled-content> information to derive longitudinal strain and <jats:styled-content style="fixed-case">SR</jats:styled-content> from high frame rate <jats:styled-content style="fixed-case">TDI</jats:styled-content> recordings. Measurements of longitudinal systolic strain (S) and global S (<jats:styled-content style="fixed-case">GLS</jats:styled-content>) made with the two methods were compared with Bland–Altman plots and Deming regression. Receiver operating characteristics (<jats:styled-content style="fixed-case">ROC</jats:styled-content>) curves were used to compare discrimination between healthy individuals and patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Mean S was −20.11 ± 4.85% (healthy) and −16.12 ± 4.44% (<jats:styled-content style="fixed-case">CMP</jats:styled-content>) with <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐<jats:styled-content style="fixed-case">ST</jats:styled-content> and −21.15 ± 5.68% (healthy) and −16.27 ± 6.44 (<jats:styled-content style="fixed-case">CMP</jats:styled-content>) with <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐manual. Using all measured segments, the mean bias was 0.78% strain toward less negative S with <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐<jats:styled-content style="fixed-case">ST</jats:styled-content>; the Deming regression slope was 0.7 for S and 0.9 for <jats:styled-content style="fixed-case">GLS</jats:styled-content>. Intra‐ and inter‐observer <jats:styled-content style="fixed-case">CV</jats:styled-content>s were 5.4% and 7.0%, respectively. <jats:styled-content style="fixed-case">ROC</jats:styled-content> curves showed no significant differences between the methods.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The described S and <jats:styled-content style="fixed-case">SR</jats:styled-content> measurements with <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐<jats:styled-content style="fixed-case">ST</jats:styled-content> are comparable to conventional manual analysis. Thus, using <jats:styled-content style="fixed-case">TDI</jats:styled-content>‐<jats:styled-content style="fixed-case">ST</jats:styled-content>, it is possible to quickly and easily extract high‐resolution deformation data.</jats:p></jats:sec>