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Medientyp:
E-Artikel
Titel:
Nutrient sensing, growth and senescence
Beteiligte:
Carroll, Bernadette;
Korolchuk, Viktor I.
Erschienen:
Wiley, 2018
Erschienen in:The FEBS Journal
Sprache:
Englisch
DOI:
10.1111/febs.14400
ISSN:
1742-464X;
1742-4658
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Cell growth is dictated by a wide range of mitogenic signals, the amplitude and relative contribution of which vary throughout development, differentiation and in a tissue‐specific manner. The ability to sense and appropriately respond to changes in mitogens is fundamental to control cell growth, and reduced responsiveness of nutrient sensing pathways is widely associated with human disease and ageing. Cellular senescence is an important tumour suppressor mechanism that is characterised by an irreversible exit from the cell cycle in response to replicative exhaustion or excessive <jats:styled-content style="fixed-case">DNA</jats:styled-content> damage. Despite the fact that senescent cells can no longer divide, they remain metabolically active and display a range of pro‐growth phenotypes that are supported in part by the <jats:styled-content style="fixed-case">mTORC</jats:styled-content>1‐autophagy signalling axis. As our understanding of the basic mechanisms of controlling <jats:styled-content style="fixed-case">mTORC</jats:styled-content>1‐autophagy activity and cell growth continues to expand, we are able to explore how changes in nutrient sensing contribute to the acquisition and maintenance of cellular senescence. Furthermore, while the protective effect of senescence to limit cellular transformation is clear, more recently, the age‐related accumulation of these pro‐inflammatory senescent cells has been shown to contribute to a decline in organismal fitness. We will further discuss whether dysregulation of nutrient sensing pathways can be targeted to promote senescent cell death which would have important implications for healthy ageing.</jats:p>