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Medientyp:
E-Artikel
Titel:
Apoptosis – Fueling the oncogenic fire
Beteiligte:
Castillo Ferrer, Camila;
Berthenet, Kevin;
Ichim, Gabriel
Erschienen:
Wiley, 2021
Erschienen in:
The FEBS Journal, 288 (2021) 15, Seite 4445-4463
Sprache:
Englisch
DOI:
10.1111/febs.15624
ISSN:
1742-464X;
1742-4658
Entstehung:
Anmerkungen:
Beschreibung:
Apoptosis, the most extensively studied form of programmed cell death, is essential for organismal homeostasis. Apoptotic cell death has widely been reported as a tumor suppressor mechanism. However, recent studies have shown that apoptosis exerts noncanonical functions and may paradoxically promote tumor growth and metastasis. The hijacking of apoptosis by cancer cells may arise at different levels, either via the interaction of apoptotic cells with their local or distant microenvironment, or through the abnormal pro‐oncogenic roles of the main apoptosis effectors, namely caspases and mitochondria, particularly upon failed apoptosis. In this review, we highlight some of the recently described mechanisms by which apoptosis and these effectors may promote cancer aggressiveness. We believe that a better understanding of the noncanonical roles of apoptosis may be crucial for developing more efficient cancer therapies.