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Medientyp:
E-Artikel
Titel:
NAD and ADP‐ribose metabolism in mitochondria
Beteiligte:
Dölle, Christian;
Rack, Johannes G.M.;
Ziegler, Mathias
Erschienen:
Wiley, 2013
Erschienen in:The FEBS Journal
Sprache:
Englisch
DOI:
10.1111/febs.12304
ISSN:
1742-464X;
1742-4658
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Mitochondrial metabolism is intimately connected to the universal coenzyme <jats:styled-content style="fixed-case">NAD</jats:styled-content>. In addition to its role in redox reactions of energy transduction, <jats:styled-content style="fixed-case">NAD</jats:styled-content> serves as substrate in regulatory reactions that lead to its degradation. Importantly, all types of the known <jats:styled-content style="fixed-case">NAD</jats:styled-content>‐consuming signalling reactions have been reported to take place in mitochondria. These reactions include the generation of second messengers, as well as post‐translational protein modifications such as <jats:styled-content style="fixed-case">ADP</jats:styled-content>‐ribosylation and protein deacetylation. Therefore, the availability and redox state of <jats:styled-content style="fixed-case">NAD</jats:styled-content> emerged as important factors in the regulation of mitochondrial metabolism. Molecular mechanisms and targets of mitochondrial <jats:styled-content style="fixed-case">NAD</jats:styled-content>‐dependent protein deacetylation and mono‐<jats:styled-content style="fixed-case">ADP</jats:styled-content>‐ribosylation have been established, whereas poly‐<jats:styled-content style="fixed-case">ADP</jats:styled-content>‐ribosylation and <jats:styled-content style="fixed-case">NAD</jats:styled-content>‐derived messenger generation in the organelles await in‐depth characterization. In this review, we highlight the major <jats:styled-content style="fixed-case">NAD</jats:styled-content>‐dependent reactions occurring within mitochondria and describe their metabolic and regulatory functions. We also discuss the metabolic fates of the <jats:styled-content style="fixed-case">NAD</jats:styled-content>‐degradation products, nicotinamide and <jats:styled-content style="fixed-case">ADP</jats:styled-content>‐ribose, and how the mitochondrial <jats:styled-content style="fixed-case">NAD</jats:styled-content> pool is restored.</jats:p>