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Medientyp:
E-Artikel
Titel:
Anti‐inflammatory and anti‐bacterial properties of tetramethylhexadecenyl succinyl cysteine (TSC): a skin‐protecting cosmetic functional ingredient
Beteiligte:
Fernandéz, J. R.;
Rouzard, K.;
Voronkov, M.;
Huber, K. L.;
Stock, J. B.;
Stock, M.;
Gordon, J. S.;
Pérez, E.
Erschienen:
Wiley, 2015
Erschienen in:International Journal of Cosmetic Science
Beschreibung:
<jats:title>Synopsis</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The skin is the first line of defence against exposure to microbial, physical, environmental and chemical insults. In mobilizing a protective response, several different cell types located in our skin release and respond to pro‐inflammatory cytokines ensuring skin homeostasis and health. However, chronic activation of this response eventually causes damage resulting in premature ageing. Diosodium tetramethylhexadecenyl succinyl cysteine (<jats:styled-content style="fixed-case">TSC</jats:styled-content> or <jats:styled-content style="fixed-case">SIG</jats:styled-content>1273), an isoprenylcysteine small molecule, down modulates these inflammatory signalling pathways in various cell types (keratinocytes, peripheral blood mononuclear cells (<jats:styled-content style="fixed-case">PBMC</jats:styled-content>s) and endothelial cells) and possesses anti‐bacterial properties. Thus, <jats:styled-content style="fixed-case">TSC</jats:styled-content> represents a novel cosmetic functional ingredient that provides a broad spectrum of benefits for the skin.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To assess the anti‐inflammatory properties of <jats:styled-content style="fixed-case">TSC</jats:styled-content> in several cutaneous cell types and further investigate its anti‐microbial activity.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Cultured normal human epidermal keratinocytes were exposed to chemical irritant phorbol 12‐myrisate 13‐acetate (<jats:styled-content style="fixed-case">TPA</jats:styled-content>) or ultraviolet‐B light (<jats:styled-content style="fixed-case">UVB</jats:styled-content>) to induce pro‐inflammatory cytokine (<jats:styled-content style="fixed-case">IL</jats:styled-content>‐6, <jats:styled-content style="fixed-case">IL</jats:styled-content>‐8 and <jats:styled-content style="fixed-case">TNF</jats:styled-content>‐<jats:italic>α</jats:italic>) production. T‐cell receptor (<jats:styled-content style="fixed-case">TCR</jats:styled-content>) activation of <jats:styled-content style="fixed-case">PBMC</jats:styled-content>s and nickel (Ni<jats:sup>2+</jats:sup>) treatments of human dermal microvascular endothelial cells (<jats:styled-content style="fixed-case">HDMEC</jats:styled-content>s) were performed resulting in <jats:styled-content style="fixed-case">IL</jats:styled-content>‐4, <jats:styled-content style="fixed-case">IL</jats:styled-content>‐6, <jats:styled-content style="fixed-case">IL</jats:styled-content>‐8 and <jats:styled-content style="fixed-case">IL</jats:styled-content>‐17 production. <jats:italic><jats:styled-content style="fixed-case">S</jats:styled-content>treptococcus pyogenes</jats:italic> were cultured to determine minimal inhibitory concentration values.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p><jats:italic>In vitro</jats:italic> studies demonstrate <jats:styled-content style="fixed-case">TSC</jats:styled-content> blocks <jats:styled-content style="fixed-case">TPA</jats:styled-content> and <jats:styled-content style="fixed-case">UVB</jats:styled-content>‐induced cytokine production in cultured keratinocytes. Similarly, <jats:styled-content style="fixed-case">TSC</jats:styled-content> inhibits overproduction of <jats:styled-content style="fixed-case">IL</jats:styled-content>‐4 and <jats:styled-content style="fixed-case">IL</jats:styled-content>‐17 in T‐cell receptor (<jats:styled-content style="fixed-case">TCR</jats:styled-content>)‐activated <jats:styled-content style="fixed-case">PBMC</jats:styled-content>s as well as nickel induction of <jats:styled-content style="fixed-case">IL</jats:styled-content>‐6 and <jats:styled-content style="fixed-case">IL</jats:styled-content>‐8 in <jats:styled-content style="fixed-case">HDMEC</jats:styled-content>s. Lastly, <jats:styled-content style="fixed-case">TSC</jats:styled-content> demonstrated anti‐microbial properties, inhibiting cell growth of <jats:italic><jats:styled-content style="fixed-case">S</jats:styled-content>. pyogenes</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Tetramethylhexadecenyl succinyl cysteine represents a novel cosmetic functional ingredient that provides a dual modulating benefit of skin protection to individuals by reducing inflammation in keratinocytes, endothelial and mononuclear cell types and <jats:italic><jats:styled-content style="fixed-case">S</jats:styled-content>. pyogenes</jats:italic> counts.</jats:p></jats:sec>