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Vandendijck, Yannick; Scott, Jane; Heerwegh, Dirk; Van Der Elst, Wim; Witek, James; Sinha, Rekha; Fennema, Hein

Measuring respiratory syncytial virus infection severity in hospitalized children using the Pediatric Respiratory Syncytial Virus Electronic Severity and Outcome Rating System (PRESORS)

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  • Medientyp: E-Artikel
  • Titel: Measuring respiratory syncytial virus infection severity in hospitalized children using the Pediatric Respiratory Syncytial Virus Electronic Severity and Outcome Rating System (PRESORS)
  • Beteiligte: Vandendijck, Yannick; Scott, Jane; Heerwegh, Dirk; Van Der Elst, Wim; Witek, James; Sinha, Rekha; Fennema, Hein
  • Erschienen: Wiley, 2022
  • Erschienen in: Influenza and Other Respiratory Viruses
  • Sprache: Englisch
  • DOI: 10.1111/irv.13028
  • ISSN: 1750-2640; 1750-2659
  • Schlagwörter: Infectious Diseases ; Public Health, Environmental and Occupational Health ; Pulmonary and Respiratory Medicine ; Epidemiology
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The Pediatric Respiratory Syncytial Virus Electronic Severity and Outcome Rating System (PRESORS) was developed to assess the severity of respiratory syncytial virus (RSV) infection in children. Because young children cannot report how they feel or function, ratings are based on observations by the child's caregiver (Observer‐Reported Outcome questionnaire [ObsRO]) and clinician (Clinician‐Reported Outcome questionnaire [ClinRO]). This prospective study aimed to evaluate the psychometric properties of the PRESORS.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The PRESORS version 6 ObsRO and ClinRO were evaluated in children with RSV infection requiring hospitalization in centers in the United States, Argentina, and Chile. Assessments were performed from days 1 to 7 by the child's caregiver and clinician. To assess inter‐rater reliability, two clinicians independently performed the ClinRO near in time.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 124 children aged ≤36 months were enrolled (mean age, 8 months). Factor analysis demonstrated that RSV severity consists of two dimensions, <jats:italic>respiratory signs</jats:italic> and <jats:italic>illness behavior</jats:italic>, and that these dimensions were consistent over time. The inter‐rater reliability for the ClinRO was 0.66 (95% confidence interval [CI], 0.55–0.75) but improved to 0.79 (95% CI, 0.71–0.86) after removing one outlying site, suggesting that quantifying RSV severity is not trivial, even using qualified raters, but that an adequate inter‐rater reliability is achievable with the PRESORS through adequate training. ClinRO and ObsRO displayed acceptable internal consistency and acceptable convergent validity with the Respiratory Syncytial Virus Network Scale, global impression scores, and key hospital characteristics.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The PRESORS is relevant and appropriate for assessing the severity of RSV infection in infants requiring hospitalization.</jats:p></jats:sec>
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