DI MARIO, FRANCESCO;
MOUSSA, ALI M;
DAL BÒ, NADIA;
CARUANA, PIETRO;
PILOTTO, ALBERTO;
CAVALLARO, LUCAS G;
CAVESTRO, GIULIA M;
IORI, VERONICA;
MERLI, ROBERTA;
FRANZÉ, ANGELO;
RUGGE, MASSIMO
Recovery of gastric function after Helicobacter pylori eradication in subjects with body atrophic gastritis: Prospective 4‐year study
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Medientyp:
E-Artikel
Titel:
Recovery of gastric function after Helicobacter pylori eradication in subjects with body atrophic gastritis: Prospective 4‐year study
Beteiligte:
DI MARIO, FRANCESCO;
MOUSSA, ALI M;
DAL BÒ, NADIA;
CARUANA, PIETRO;
PILOTTO, ALBERTO;
CAVALLARO, LUCAS G;
CAVESTRO, GIULIA M;
IORI, VERONICA;
MERLI, ROBERTA;
FRANZÉ, ANGELO;
RUGGE, MASSIMO
Erschienen:
Wiley, 2005
Erschienen in:
Journal of Gastroenterology and Hepatology, 20 (2005) 11, Seite 1661-1666
Beschreibung:
AbstractBackground: The relationship between Helicobacter pylori (H. pylori) eradication and atrophic changes in the gastric mucosa has not yet been fully defined. Although studies report a partial restoration of serum pepsinogen I (sPGI) levels after eradication, it is not clear if this finding reflects gastric mucosal healing on a morphological level.Aim: To assess alterations in gastric function after H. pylori eradication on moderate/severe body atrophic gastritis by determination of sPGI levels.Methods: Twenty‐three dyspeptic patients, selected from 284 consecutive H. pylori positive patients, with histological features of moderate/severe body atrophic gastritis and sPGI < 25 µg/L (11 men, mean age: 51.8 years, range: 29–79 years), underwent an upper gastrointestinal endoscopy with gastric biopsies and sPGI determination at baseline. All patients underwent eradication therapy. Serum pepsinogen I was measured again after 6 months, and at 1, 2, 3 and 4 years after eradication therapy.Results: Mean sPGI levels prior to eradication were 11.9 µg/L (range: 4–23 µg/L). Six months after eradication therapy, mean sPGI levels significantly increased to 17.4 µg/L (P = 0.04). At the completion of the study, 4 years after eradication, sPGI levels increased from 17.4 to 32.7 µg/L (P = 0.01). A significant progressive increase in sPGI levels was observed from 6 months to 1 year (17.4 to 23.9 µg/L) and from 1 to 2 years (23.9 to 26.0 µg/L, P = 0.01). Serum pepsinogen I levels higher than the cut‐off value of 25 µg/L were observed at various time‐points: 6.3% of patients at 6 months (1/16), 33.3% (5/15) at 1 year, 50% (7/14) at 24 months, 66.7% (6/9) at 36 months and 87.5% (7/8) at 4 years.Conclusion: After H. pylori eradication, subjects with body atrophic gastritis showed long‐term improvement of physiological gastric function, reflected by significantly and continually increasing sPGI levels over a 4‐year period.