> Detailanzeige

Bioulac‐Sage, Paulette; Taouji, Said; Possenti, Laurent; Balabaud, Charles

Hepatocellular adenoma subtypes: the impact of overweight and obesity

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Hepatocellular adenoma subtypes: the impact of overweight and obesity
  • Beteiligte: Bioulac‐Sage, Paulette; Taouji, Said; Possenti, Laurent; Balabaud, Charles
  • Erschienen: Wiley, 2012
  • Erschienen in: Liver International, 32 (2012) 8, Seite 1217-1221
  • Sprache: Englisch
  • DOI: 10.1111/j.1478-3231.2012.02786.x
  • ISSN: 1478-3223; 1478-3231
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Hepatocellular adenomas (<jats:styled-content style="fixed-case">HCA</jats:styled-content>) are rare benign tumours occurring mainly in women using oral contraceptives. With the appearance of a generation of new oral contraceptives, the number of <jats:styled-content style="fixed-case">HCA</jats:styled-content> cases was anticipated to decrease, but in fact this was not observed in our practice. The influence of obesity was therefore suspected as a new co‐factor.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>The aim of this study was to analyze the impact of overweight/obesity in our cohort of <jats:styled-content style="fixed-case">HCA</jats:styled-content> patients classified according to their subtypes.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The number of <jats:styled-content style="fixed-case">HCA</jats:styled-content> noticeably increased faster in the 2001–2011 period compared to the 1990–2000 period. This phenomenon concurred with an increasing number of patients overweight or obese. Females still represented the great majority of overweight/obese patients presenting <jats:styled-content style="fixed-case">HCA</jats:styled-content>, however, overweight/obese male patients constituted a new entity in the inflammatory <jats:styled-content style="fixed-case">HCA</jats:styled-content> and β‐catenin activated‐ inflammatory <jats:styled-content style="fixed-case">HCA</jats:styled-content> subgroups.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>We propose that overweight/obesity may soon represent a major risk of malignant transformation of <jats:styled-content style="fixed-case">HCA</jats:styled-content>, possibly via the <jats:styled-content style="fixed-case">IL</jats:styled-content>‐6 pathway.</jats:p></jats:sec>