Beschreibung:
SummaryAdministration of kainic acid generates a syndrome of seizures and brain damage that mimics temporal lobe epilepsy (TLE) and has provided many basic concepts of relevant to the epilepsies—mechanisms of cell death, failure of inhibition, sprouting and neosynapse formation, and how seizures begets seizures. In addition, kainatergic synapses are enriched on vulnerable neurons, a form of plasticity that stresses their unique physiologic roles. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado‐Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).