Second donation of granulocyte–colony‐stimulating factor–mobilized peripheral blood progenitor cells: risk factors associated with a low yield of CD34+ cells
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Medientyp:
E-Artikel
Titel:
Second donation of granulocyte–colony‐stimulating factor–mobilized peripheral blood progenitor cells: risk factors associated with a low yield of CD34+ cells
Erschienen in:
Transfusion, 45 (2005) 1, Seite 11-15
Sprache:
Englisch
DOI:
10.1111/j.1537-2995.2005.04107.x
ISSN:
0041-1132;
1537-2995
Entstehung:
Anmerkungen:
Beschreibung:
BACKGROUND: There are still limited data on the efficacy and safety of repeated donations of granulocyte–colony‐stimulating factor (G–CSF)‐mobilized peripheral blood progenitor cells (PBPCs) for allogeneic transplantation.STUDY DESIGN AND METHODS: Sixty‐seven healthy donors undergoing two consecutive mobilizations of PBPCs within a median interval of 5 months (range, 0.1‐47 months) were investigated. For both first mobilization (FM) and second mobilization (SM), G–CSF (lenograstim) at 7.5 µg per kg per day was administered.RESULTS: The nonhematologic side effects were comparable between both mobilizations. A significantly lower yield of CD34+ cells × 106 per kg of donor weight was obtained on Day 5 of SM in female (n = 31; FM, 5.0; SM, 3.23; p = 0.008) but not in male (n = 36; FM, 5.96; SM, 5.36; p = 0.24) donors. Multivariate analysis identified a lower CD34+ blood concentration on Day 5 of FM (p < 0.001) as well as female sex (p = 0.015) as independent risk factors for a lower yield of progenitor cells, whereas donor age and body mass index, interval between donations, and schedule of G–CSF application showed no significant impact.CONCLUSION: The identified risk factors allow the estimation of the efficacy of a SM in an individual donor before G–CSF administration, thus avoiding distress to both the donor and the recipient.