Left atrial volume index as a predictor of ventricle repolarization abnormalities in adult dialyzed patients

Medientyp: E-Artikel
Titel: Left atrial volume index as a predictor of ventricle repolarization abnormalities in adult dialyzed patients
Beteiligte: Zapolski, Tomasz; Jaroszyński, Andrzej; Drelich‐Zbroja, Anna; Furmaga, Jacek; Wysokiński, Andrzej; Książek, Andrzej; Szczerbo‐Trojanowska, Małgorzata; Rudzki, Sławomir
Erschienen: Wiley, 2012
Erschienen in: Hemodialysis International, 16 (2012) 2, Seite 220-232
Sprache: Englisch
DOI: 10.1111/j.1542-4758.2012.00668.x
ISSN: 1492-7535; 1542-4758
Schlagwörter: Nephrology ; Hematology
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>This study was performed to investigate the relationship between left atrium (<jats:styled-content style="fixed-case">LA</jats:styled-content>) volume index (<jats:styled-content style="fixed-case">LAVI</jats:styled-content>) and left ventricle electrical activity presumably repolarization in end‐stage renal disease patients. Study group was consisted of 120 dialyzed patients divided into two subgroups: 57 (age 50.7 ± 7.1) were on continuous ambulatory peritoneal dialysis (<jats:styled-content style="fixed-case">CAPD</jats:styled-content>) and 73 (age 51.6 ± 7.6) were hemodialyzed (<jats:styled-content style="fixed-case">HD</jats:styled-content>). All patients were undergoing three‐dimensional vectorcardiographic (<jats:styled-content style="fixed-case">VCG</jats:styled-content>) monitoring to assess parameters concerning <jats:styled-content style="fixed-case">T</jats:styled-content> vector: <jats:styled-content style="fixed-case">QRS</jats:styled-content>‐<jats:styled-content style="fixed-case">T</jats:styled-content> angle, Tel, and Taz. Standard echocardiography was performed to assess: <jats:styled-content style="fixed-case">LA<jats:sub>max</jats:sub></jats:styled-content>, <jats:styled-content style="fixed-case">LA<jats:sub>short</jats:sub></jats:styled-content>, <jats:styled-content style="fixed-case">LA<jats:sub>long</jats:sub></jats:styled-content>. <jats:styled-content style="fixed-case">LAVI</jats:styled-content> was calculated due to formula: <jats:styled-content style="fixed-case">LAVI</jats:styled-content> = (π/6X [LA<jats:sub>max</jats:sub> × LA<jats:sub>short</jats:sub> × LA<jats:sub>long</jats:sub>])/m<jats:sup>2</jats:sup>. <jats:styled-content style="fixed-case">LAVI</jats:styled-content> in <jats:styled-content style="fixed-case">HD</jats:styled-content> as well as in <jats:styled-content style="fixed-case">CAPD</jats:styled-content> patients was significantly higher compared with controls (respectively: 36.29 ± 10.92; 36.41 ± 11.06; 20.64 ± 6.77 <jats:styled-content style="fixed-case">mL</jats:styled-content>/m<jats:sup>2</jats:sup>). The calculated cutoff value of <jats:styled-content style="fixed-case">LAVI</jats:styled-content> was 36.32 <jats:styled-content style="fixed-case">mL</jats:styled-content>/m<jats:sup>2</jats:sup>. In <jats:styled-content style="fixed-case">HD</jats:styled-content> patients, the strong correlations between <jats:styled-content style="fixed-case">LAVI</jats:styled-content> and <jats:styled-content style="fixed-case">QRS</jats:styled-content>‐<jats:styled-content style="fixed-case">T</jats:styled-content> angle and <jats:styled-content style="fixed-case">T</jats:styled-content>el were determined (respectively: <jats:styled-content style="fixed-case"><jats:italic>r</jats:italic></jats:styled-content> = 0.407, <jats:styled-content style="fixed-case">P</jats:styled-content> < 0.001 and <jats:styled-content style="fixed-case"><jats:italic>r</jats:italic></jats:styled-content> = 0.359, <jats:styled-content style="fixed-case">P</jats:styled-content> = 0.006). Similarly in <jats:styled-content style="fixed-case">CAPD</jats:styled-content> group were significant associations between <jats:styled-content style="fixed-case">LAVI</jats:styled-content> and <jats:styled-content style="fixed-case">QRS</jats:styled-content>‐<jats:styled-content style="fixed-case">T</jats:styled-content> angle and <jats:styled-content style="fixed-case">T</jats:styled-content>el (respectively: <jats:styled-content style="fixed-case"><jats:italic>r</jats:italic></jats:styled-content> = 0.423, <jats:styled-content style="fixed-case">P</jats:styled-content> < 0.001 and <jats:styled-content style="fixed-case"><jats:italic>r</jats:italic></jats:styled-content> = 0.374, <jats:styled-content style="fixed-case">P</jats:styled-content> = 0.004). The <jats:styled-content style="fixed-case">QRS</jats:styled-content>‐<jats:styled-content style="fixed-case">T</jats:styled-content> angle, <jats:styled-content style="fixed-case">T</jats:styled-content>el and <jats:styled-content style="fixed-case">T</jats:styled-content>az are independently and markedly associated with <jats:styled-content style="fixed-case">LAVI</jats:styled-content> in both <jats:styled-content style="fixed-case">HD</jats:styled-content> and <jats:styled-content style="fixed-case">CAPD</jats:styled-content> patients. <jats:styled-content style="fixed-case">LAVI</jats:styled-content> and <jats:styled-content style="fixed-case">VCG</jats:styled-content> indices are higher in both <jats:styled-content style="fixed-case">HD</jats:styled-content> and <jats:styled-content style="fixed-case">CAPD</jats:styled-content> patients. Correlation between <jats:styled-content style="fixed-case">QRS</jats:styled-content>‐<jats:styled-content style="fixed-case">T</jats:styled-content> angle and <jats:styled-content style="fixed-case">LAVI</jats:styled-content> may reflect unfavorable influence on the electrical activity of the heart in dialyzed patients with left ventricle diastolic dysfunction. <jats:styled-content style="fixed-case">LAVI</jats:styled-content> cutoff value is useful biomarker for stratification of ventricle repolarization disturbances in those patients.</jats:p>

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