DE MATOS, AUGUSTO JOSÉ FERREIRA;
LOPES, CÉLIA CRISTINA CARREIRAS;
FAUSTINO, AUGUSTO MANUEL RODRIGUES;
CARVALHEIRA, JÚLIO GIL VALE;
RUTTEMAN, GERARD ROEL;
GÄRTNER, MARIA DE FÁTIMA RODRIGUES MOUTINHO
E‐cadherin, β‐catenin, invasion and lymph node metastases in canine malignant mammary tumours
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Medientyp:
E-Artikel
Titel:
E‐cadherin, β‐catenin, invasion and lymph node metastases in canine malignant mammary tumours
Beteiligte:
DE MATOS, AUGUSTO JOSÉ FERREIRA;
LOPES, CÉLIA CRISTINA CARREIRAS;
FAUSTINO, AUGUSTO MANUEL RODRIGUES;
CARVALHEIRA, JÚLIO GIL VALE;
RUTTEMAN, GERARD ROEL;
GÄRTNER, MARIA DE FÁTIMA RODRIGUES MOUTINHO
Beschreibung:
<jats:p>Recent studies of canine malignant mammary tumours suggest that reduction of E‐cadherin and/or β‐catenin correlates with invasive behaviour and lymph node metastasis. The aims of this study were to examine the interrelationships between the expression of E‐cadherin and β‐catenin, and the relationship between the expression of E‐cadherin and/or β‐catenin and the mode of growth and metastatic capacity of canine malignant mammary tumours. 90 spontaneous malignant tumours and local and regional lymph nodes were studied. A significant relationship was evidenced between membranous expression of E‐cadherin and β‐catenin (p=0.0027), but not between E‐cadherin and cytoplasmic β‐catenin. Only E‐cadherin as a separate factor was significantly related to tumour invasion (p=0.0072) and lymph node metastasis (p=0.0001). Neither membranous nor cytoplasmic β‐catenin expression was significantly related to either of these phenomena.</jats:p>