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Medientyp:
E-Artikel
Titel:
Cell Proliferation in the Lichen Planus Infiltrate : Investigations by Light‐ and Electron‐ Microscopic Autoradiography
:
Investigations by Light‐ and Electron‐ Microscopic Autoradiography
Beteiligte:
EBNER, HERWIG;
JURECKA, WOLFGANG
Erschienen:
Wiley, 1977
Erschienen in:
Journal of Cutaneous Pathology, 4 (1977) 4, Seite 185-190
Beschreibung:
In seven patients suffering from lichen planus (LP) light‐ and electron‐microscopic 3H‐thymidine (3HT) labeling studies were performed and the following results were obtained. 1. Using the light‐microscope, a large number of 3HT labeled cells can be observed in the dermal infiltrate of LP. Most of the labeled nuclei belong to mononuclear, ‘round cells’ while isolated endothelial cells. fibroblasts, histiocytes and mast cells could be found labeled. 2. The mean labeling index of ‘round cells’ in our patients was 4.27 ± 1.57%. 3. The evaluation of the electron microscopic autoradio‐graphs showed that, as far as ‘round’ cells were concerned, exclusively nuclei of cells showing the morphological criteria of stimulated lymphocytes were labeled. These findings support the view that in LP, as in allergic contact dermatitis, a high proliferative activity of lymphocytes takes place.