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Wagner, Judith; Kaminski, Wolfgang E.; Aslanidis, Charalampos; Moder, Daniel; Hiller, Karl‐Anton; Christgau, Michael; Schmitz, Gerd; Schmalz, Gottfried

Prevalence of OPG and IL‐1 gene polymorphisms in chronic periodontitis

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  • Medientyp: E-Artikel
  • Titel: Prevalence of OPG and IL‐1 gene polymorphisms in chronic periodontitis
  • Beteiligte: Wagner, Judith; Kaminski, Wolfgang E.; Aslanidis, Charalampos; Moder, Daniel; Hiller, Karl‐Anton; Christgau, Michael; Schmitz, Gerd; Schmalz, Gottfried
  • Erschienen: Wiley, 2007
  • Erschienen in: Journal of Clinical Periodontology, 34 (2007) 10, Seite 823-827
  • Sprache: Englisch
  • DOI: 10.1111/j.1600-051x.2007.01132.x
  • ISSN: 0303-6979; 1600-051X
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: AbstractAim: To investigate the association of polymorphisms in the osteoprotegerin (OPG) and interleukin 1 (IL‐1) genes with chronic periodontitis (CP).Material and Methods: One hundred and ninety‐four individuals (97 CP patients, 97 controls) were genotyped for the OPG polymorphisms Lys3Asn and Met256Val and for the IL‐1 polymorphisms IL‐1A (−889C/T) and IL‐1B (+3953C/T).Results: The homozygous variants coding for Lys3 were present at a higher frequency, whereas Asn3 and Met256 were present at a lower frequency in CP patients/controls (Lys3: 31%/25%, Asn3: 23%/32% and Met256: 66%/73%). Heterozygosity for Lys3Asn was observed at a higher frequency in CP patients/controls (46%/43%). Homozygosity for the Val256 genotype was observed in two CP patients (one in controls). Met256Val heterozygosity was more prevalent in CP patients/controls (32%/20%). All differences were statistically not significant between CP patients and controls. In contrast, both IL‐1 polymorphisms were statistically significant. The heterozygous variant for IL‐1A was present in 32% of the CP patients and in 20% of the controls (homozygosity (patients/controls) CC: 10%/21% and TT: 55%/33%). Heterozygosity for IL‐1B was observed in 37% of the CP patients versus 34% in the controls (homozygosity (patients/controls) CC: 26%/57% and TT: 37%/9%).Conclusion: While the association between the IL‐1 polymorphisms and CP was confirmed, no association between the OPG polymorphisms and CP could be found.