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Bagan, Jose V.; Mata‐Roig, Manuel; Cortio‐Gimeno, Julio; Murillo‐Cortes, Judith; Hens‐Aumente, Elena; Poveda‐Roda, Rafael; Bagan, Leticia

Epidermal growth factor receptor copy number in potentially malignant oral disorders and oral squamous cell carcinoma: a short communication and preliminary study

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  • Medientyp: E-Artikel
  • Titel: Epidermal growth factor receptor copy number in potentially malignant oral disorders and oral squamous cell carcinoma: a short communication and preliminary study
  • Beteiligte: Bagan, Jose V.; Mata‐Roig, Manuel; Cortio‐Gimeno, Julio; Murillo‐Cortes, Judith; Hens‐Aumente, Elena; Poveda‐Roda, Rafael; Bagan, Leticia
  • Erschienen: Wiley, 2012
  • Erschienen in: Journal of Oral Pathology & Medicine, 41 (2012) 9, Seite 662-666
  • Sprache: Englisch
  • DOI: 10.1111/j.1600-0714.2012.01137.x
  • ISSN: 0904-2512; 1600-0714
  • Schlagwörter: Periodontics ; Cancer Research ; Otorhinolaryngology ; Oral Surgery ; Pathology and Forensic Medicine
  • Entstehung:
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  • Beschreibung: J Oral Pathol Med (2012) 41: 662–666Introduction:  This preliminary study compared the epidermal growth factor receptor (EGFR) copy number in patients with potentially malignant oral disorders (PMODs) and oral squamous cell carcinoma (OSCC).Material and methods:  Group 1 comprised 20 patients with oral leukoplakia and group 2 comprised 19 cases of OSCC. We estimated the EGFR copy number in both groups using real‐time reverse‐transcription polymerase chain reaction assays. We used laser microdissection (LMD) for EGFR amplification, and overexpression was performed.Results:  The EGFR copy number was higher in group 2 (9.1 ± 6.2) than in group 1 (3.8 ± 1.5). The greatest copy number was found in the non‐homogeneous leukoplakias, but the difference in homogeneous cases was not significant (Mann–Whitney test, P > 0.05). In group 2, the EGFR copy number was higher in advanced stages than in early stages, but again lacked statistical significance.Conclusions:  The EGFR copy number may be a useful biomolecular marker to differentiate PMODs from OSCC. The EGFR was higher in non‐homogeneous leukoplakias and in the advanced stages of OSCC.