Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Aim: To evaluate the influence of maternal smoking during pregnancy on factors influencing fetal growth.</jats:p><jats:p>Methods: Thirty newborns of smoking mothers were prospectively compared with 60 newborns of non‐smoking mothers. Pre‐albumin, albumin, triglycerides, glucose, insulin, insulin‐like growth factor I, IGF binding protein 3, pH, lactic acid, erythropoietin and hemoglobin concentrations were measured in umbilical cord blood.</jats:p><jats:p>Results: Infants of smoking mothers had a significantly lower birth weight (3418 ± 533 vs. 3863 ± 503 g; p < 0.001), length (50.5 ± 2,6 vs. 52.3 ± 1.9 cm; p < 0.001) and head circumference (34.6 ± 1.8 vs. 35.8 ± 1.1 cm; p < 0.001) than controls. They also had significantly lower insulin (3.2 (2.0–4.9) vs. 5.8 (4.6–7.1) mU/L; p = 0.008), insulin‐like growth factor I (54.4 ± 32.5 vs. 93.8 ± 54.5 μg/L; p = 0.001) and IGF binding protein 3 (1664 ± 432 vs. 1943 ± 421 μg/L; p = 0.01) concentrations, than controls. Infants of smoking mothers also had significantly higher hemoglobin (167 ± 14 vs. 157 ± 13 g/L; p = 0.002) and erythropoietin (42.3 (25.1–72.4) vs. 26.3 (21.9–30.9) U/L; p = 0.03) than controls, but not pH or lactate concentrations. There was no significant difference in pre‐albumin, albumin, triglycerides and glucose concentrations.</jats:p><jats:p>Conclusions: Smoking during pregnancy causes symmetrical fetal growth impairment, possibly due to decreased oxygen transport to the fetus and decreased concentrations of fetal insulin, insulin‐like growth factor I and IGF binding protein 3.</jats:p>