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Medientyp:
E-Artikel
Titel:
Use of clomipramine in treatment of obsessive‐compulsive disorder, separation anxiety and noise phobia in dogs: a preliminary, clinical study
Beteiligte:
SEKSEL, K;
LINDEMAN, MJ
Erschienen:
Wiley, 2001
Erschienen in:Australian Veterinary Journal
Sprache:
Englisch
DOI:
10.1111/j.1751-0813.2001.tb11976.x
ISSN:
0005-0423;
1751-0813
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p><jats:bold>Objective</jats:bold>To evaluate the efficacy and tolerance of a treatment protocol for obsessive‐compulsive disorder, separation anxiety and noise phobia in dogs.</jats:p><jats:p><jats:bold>Design</jats:bold>A study was undertaken to assess clinical responses in 24 dogs diagnosed with one or more of three behavioural disorders stated above to a treatment regimen that included clomipramine and behaviour modification.</jats:p><jats:p><jats:bold>Procedure</jats:bold>A detailed behavioural and clinical history was obtained for each dog. Obsessive‐compulsive disorder was diagnosed in nine cases: primary presenting complaints were tail‐chasing, shadow‐chasing, circling and chewing; one case was diagnosed with concurrent separation anxiety. Separation anxiety was diagnosed in 14 cases: presenting complaints included destruction, vocalisation and escaping in the absence of the owner; four cases also exhibited noise phobia. The study also included one dog diagnosed with noise phobia only and another with inappropriate fear responses.</jats:p><jats:p>Clomipramine was administered orally twice daily. The starting dose was 1 to 2 mg/kg bodyweight. The dose was increased incrementally to a maximum of 4 mg/kg if needed. A behaviour modification program was designed and the owner instructed on its implementation. Dogs continued medication for at least 1 month after clinical signs disappeared or were acceptably reduced, then withdrawal of medication was attempted by decreasing drug dosage at weekly intervals while behaviour modification continued.</jats:p><jats:p><jats:bold>Results</jats:bold>The presenting clinical sign was largely improved or disappeared in 16 dogs, 5 demonstrated slight to moderate improvement and the behaviour was unchanged in 3. Clomipramine withdrawal was attempted in nine cases: this was successful in five.</jats:p><jats:p><jats:bold>Conclusion</jats:bold>Clomipramine was effective and well‐tolerated in controlling signs of obsessive‐compulsive disorder and/or separation anxiety and/or noise phobia in 16 of 24 assessable cases, when used in combination with behaviour modification, and improvement in clinical signs was noted in 5 others.</jats:p>