Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Murine models of primary biliary cirrhosis: Comparisons and contrasts
Beteiligte:
Oertelt, Sabine;
Ridgway, William M.;
Ansari, Aftab A.;
Coppel, Ross L.;
Gershwin, M. Eric
Erschienen:
Wiley, 2007
Erschienen in:
Hepatology Research, 37 (2007) s3
Sprache:
Englisch
DOI:
10.1111/j.1872-034x.2007.00226.x
ISSN:
1386-6346;
1872-034X
Entstehung:
Anmerkungen:
Beschreibung:
The absence of suitable mouse models has represented a major drawback in our understanding of early events leading to the development of primary biliary cirrhosis (PBC). The recent report of not one, but three mouse models, each with distinctive features resembling PBC, represents a major advance in PBC research and generates novel experimental perspectives. The dnTGFβRII mouse, the IL‐2Rα–/– mouse and the NOD.c3c4 mouse are all characterized by different genetic backgrounds and modifications, nonetheless all develop characteristic lymphocytic biliary infiltrates and specific antimitochondrial antibody response. Each model reflects characteristics of PBC in association with unique phenotypic differences. These three distinct models will allow a better understanding of the specific genetics involved in breaking of tolerance and progression of disease, in association with the possible definition of novel therapeutic approaches.