MacEwen, E. Gregory;
Rosenthal, Robert C.;
Fox, Leslie E.;
Loar, Andrew S.;
Kurzman, Ilene D.
Evaluation of L‐asparaginase: Polyethylene Glycol Conjugate Versus Native L‐asparaginase Combined with Chemotherapy: A Randomized Double‐blind Study in Canine Lymphoma
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Medientyp:
E-Artikel
Titel:
Evaluation of L‐asparaginase: Polyethylene Glycol Conjugate Versus Native L‐asparaginase Combined with Chemotherapy: A Randomized Double‐blind Study in Canine Lymphoma
Beteiligte:
MacEwen, E. Gregory;
Rosenthal, Robert C.;
Fox, Leslie E.;
Loar, Andrew S.;
Kurzman, Ilene D.
Erschienen:
Wiley, 1992
Erschienen in:Journal of Veterinary Internal Medicine
Beschreibung:
<jats:p>L‐asparaginase is an enzyme that inhibits protein synthesis by the depletion of sources of L‐asparagine, which is necessary for transformed lymphoid cells to proliferate. L‐asparaginase is used in the treatment of childhood acute lymphoblastic leukemia. A problem with L‐asparaginase therapy is the immunogenicity of the enzyme and the development of anaphylactic reactions. Canine lymphoma is a predominantly B‐cell tumor with widespread disease; without treatment, dogs with lymphoma usually survive 1–2 months. Canine lymphoma will respond to L‐asparaginase therapy. A randomized double‐blind study evaluated a polyethylene glycol (PEG) conjugate L‐asparaginase combined with chemotherapy (vincristine, cyclophosphamide, doxorubicin, and prednisone). Thirty‐five dogs were randomized to the PEG L‐asparaginase group, and 34 dogs were randomized to the native L‐asparaginase group. Thirty dogs, (85.7%) achieved a complete remission (CR) with a median time to relapse of 217 days, and 32 (94.1%) dogs in the native L‐asparaginase group achieved a CR with a median time to relapse of 214 days (P > 0.05). The asparaginase was well tolerated in both groups. Two dogs in the native L‐asparaginase group had severe allergic reactions, and one dog in the PEG asparaginase group had a generalized urticaria1 reaction after repeated injections. This study indicates that PEG L‐asparaginase has equal therapeutic efficacy to native L‐asparaginase. (Journal of Veterinary Internal Medicine 1992; 6:230–234)</jats:p>