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Medientyp:
E-Artikel
Titel:
Clonal spread of serogroup A meningococci: a paradigm for the analysis of microevolution in bacteria
Beteiligte:
Achtman, Mark
Erschienen:
Wiley, 1994
Erschienen in:
Molecular Microbiology, 11 (1994) 1, Seite 15-22
Sprache:
Englisch
DOI:
10.1111/j.1365-2958.1994.tb00285.x
ISSN:
0950-382X;
1365-2958
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Summary</jats:title><jats:p>Extensive epidemiological analyses of epidemics of meningococcal meningitis have resulted in large, well‐defined strain collections which represent the local diversity and global spread of serogroup A bacteria. Several genes for cell surface proteins are conserved during spread, with a few exceptions: analysis of these exceptions has revealed some of the phenomena which can lead to microevolution. Micro‐evolution is so rapid with serogroup A meningococcal that several independent recombination events have been documented within the last few decades. In a few cases, the recombinant bacteria have become established by clonal replacement plus epidemic spread. Comparison with other bacteria indicates that serogroup A meningococcal provide a number of advantages for analysis of microevolution.</jats:p>