• Medientyp: E-Artikel
  • Titel: A significant productive in vivo infection of resting cells with simian immunodeficiency virus in a macaque with AIDS
  • Beteiligte: Pahar, Bapi; Lala, Wendy; Kuebler, Dot; Liu, David
  • Erschienen: Wiley, 2017
  • Erschienen in: Journal of Medical Primatology
  • Sprache: Englisch
  • DOI: 10.1111/jmp.12252
  • ISSN: 0047-2565; 1600-0684
  • Schlagwörter: General Veterinary ; Animal Science and Zoology
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)‐infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non‐proliferating resting cells. SIV‐infected non‐proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir formation.</jats:p>