Beschreibung:
<jats:p>Although growth hormone (<jats:styled-content style="fixed-case">GH)</jats:styled-content>‐ and prolactin (<jats:styled-content style="fixed-case">PRL)</jats:styled-content>‐secreting pituitary adenomas are considered benign, in many patients, tumour growth and/or invasion constitute a particular challenge. In other tumours, progression relies in part on dysfunction of intercellular adhesion mediated by the large family of cadherins. In the present study, we have explored the contribution of cadherins in <jats:styled-content style="fixed-case">GH</jats:styled-content> and <jats:styled-content style="fixed-case">PRL</jats:styled-content> adenoma pathogenesis, and evaluated whether this class of adherence molecules was related to tumour invasiveness. We have first established, by <jats:styled-content style="fixed-case">quantitative polymerase chain reaction</jats:styled-content> and immunohistochemistry, the expression profile of classical cadherins in the normal human pituitary gland. We show that the cadherin repertoire is restricted and cell‐type specific. Somatotrophs and lactotrophs express mainly E‐cadherin and cadherin 18, whereas N‐cadherin is present in the other endocrine cell types. This repertoire undergoes major differential modification in <jats:styled-content style="fixed-case">GH</jats:styled-content> and <jats:styled-content style="fixed-case">PRL</jats:styled-content> tumours: E‐cadherin is significantly reduced in invasive <jats:styled-content style="fixed-case">GH</jats:styled-content> adenomas, and this loss is associated with a cytoplasmic relocalisation of cadherin 18 and catenins. In invasive prolactinomas, E‐cadherin distribution is altered and is accompanied by a mislocalisation of cadherin 18, β‐catenin and p120 catenin. Strikingly, <jats:italic>de novo</jats:italic> expression of N‐cadherin is present in a subset of adenomas and cells exhibit a mesenchymal phenotype exclusively in invasive tumours. Binary tree analysis, performed by combining the cadherin repertoire with the expression of a subset of known molecular markers, shows that cadherin/catenin complexes play a significant role in discrimination of tumour invasion.</jats:p>