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Hagenfeld, Daniel; Prior, Karola; Harks, Inga; Jockel‐Schneider, Yvonne; May, Theodor W.; Harmsen, Dag; Schlagenhauf, Ulrich; Ehmke, Benjamin

No differences in microbiome changes between anti‐adhesive and antibacterial ingredients in toothpastes during periodontal therapy

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  • Medientyp: E-Artikel
  • Titel: No differences in microbiome changes between anti‐adhesive and antibacterial ingredients in toothpastes during periodontal therapy
  • Beteiligte: Hagenfeld, Daniel; Prior, Karola; Harks, Inga; Jockel‐Schneider, Yvonne; May, Theodor W.; Harmsen, Dag; Schlagenhauf, Ulrich; Ehmke, Benjamin
  • Erschienen: Wiley, 2019
  • Erschienen in: Journal of Periodontal Research, 54 (2019) 4, Seite 435-443
  • Sprache: Englisch
  • DOI: 10.1111/jre.12645
  • ISSN: 0022-3484; 1600-0765
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: AimThis subgroup analysis of a 12‐week randomized, double‐blind, and two‐center trial aimed to evaluate whether two different toothpaste formulations can differentially modulate the dental microbiome.Material and MethodsForty one mild to moderate periodontitis patients used as an adjunct to periodontal treatment either a toothpaste with anti‐adhesive zinc‐substituted carbonated hydroxyapatite (HA) or with antimicrobial and anti‐adhesive amine fluoride/stannous fluoride (AmF/SnF2) during a 12‐week period. Plaque samples from buccal/lingual, interproximal, and subgingival sites were taken at baseline, 4 weeks after oral hygiene phase, and 8 weeks after periodontal therapy. Samples were analyzed with paired‐end Illumina Miseq 16SrDNAsequencing. The differences and changes on community level (alpha and beta diversity) and on the level of single agglomerated ribosomal sequence variants (aRSV) were calculated with analysis of covariance (ANCOVA) and likelihood ratio test (LRT).ResultsInterproximal and subgingival sites harbored predominatelyFusobacteriumandPrevotellaspecies associated with periodontitis, whereas buccal/lingual sites harbored mainlyStreptococcusandVeillonellaspecies associated with periodontal health. Alpha and beta diversity did not change noticeably differently between both toothpaste groups (P > 0.05,ANCOVA). Furthermore, none of theaRSVs showed a noticeably different change between the tested toothpastes during periodontal therapy (Padj .> 0.05,LRT).ConclusionThe use of a toothpaste containing anti‐adhesiveHAdid not induce statistically noticeably different changes on microbial composition compared to an antimicrobial and anti‐adhesive AmF/SnF2formulation.