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Medientyp:
E-Artikel
Titel:
A fresh view of the cell biology of copper in enterobacteria
Beteiligte:
Nies, Dietrich H.;
Herzberg, Martin
Erschienen:
Wiley, 2013
Erschienen in:
Molecular Microbiology, 87 (2013) 3, Seite 447-454
Sprache:
Englisch
DOI:
10.1111/mmi.12123
ISSN:
0950-382X;
1365-2958
Entstehung:
Anmerkungen:
Beschreibung:
SummaryCopper ions are essential but also very toxic. Copper resistance in bacteria is based on export of the toxic ion, oxidation fromCu(I)toCu(II), and sequestration by copper‐binding metal chaperones, which deliver copper ions to efflux systems or metal‐binding sites of copper‐requiring proteins. In their publication in this issue,Osmanet al. () demonstrate how tightly copper resistance, homeostasis and delivery pathways are interwoven inSalmonella entericasv.Typhimurium. Copper is transported from the cytoplasm by the twoP‐typeATPasesCopAandGolTto the periplasm and transferred toSodCIIbyCueP, a periplasmic copper chaperone. When copper levels are higher,SodCIIis also able to bind copper without the help ofCueP. This scheme raises the question as to why copper ions present in the growth medium have to make the detour through the cytoplasm. The data presented in the publication byOsmanet al. () change our view of the cell biology of copper in enterobacteria.