Beschreibung:
<jats:sec><jats:title>Objective</jats:title><jats:p>Cyclooxygenase‐2 (<jats:styled-content style="fixed-case">COX</jats:styled-content>‐2) enzyme is a major mediator of inflammation in periodontitis, leading to loss of gingival tissues and alveolar bone supporting the teeth. Previous studies have explored the role of <jats:italic><jats:styled-content style="fixed-case">COX</jats:styled-content>‐2</jats:italic> polymorphisms with the risk of periodontitis in different ethnic groups; however, findings are inconsistent. So, we aimed to investigate the association of <jats:italic><jats:styled-content style="fixed-case">COX</jats:styled-content>‐2</jats:italic> polymorphisms (rs20417, rs689466, and rs5275) in susceptibility to chronic periodontitis (<jats:styled-content style="fixed-case">CP</jats:styled-content>) in northern Indian population. Meta‐analysis was also carried out to precisely estimate the effect of <jats:italic><jats:styled-content style="fixed-case">COX</jats:styled-content>‐2</jats:italic> polymorphisms in <jats:styled-content style="fixed-case">CP</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>Genotyping of <jats:italic><jats:styled-content style="fixed-case">COX</jats:styled-content>‐2</jats:italic> polymorphisms was carried out through <jats:styled-content style="fixed-case">PCR</jats:styled-content>‐<jats:styled-content style="fixed-case">RFLP</jats:styled-content> in 200 <jats:styled-content style="fixed-case">CP</jats:styled-content> cases and 200 controls. For risk estimation, binary logistic regression was applied using <jats:styled-content style="fixed-case">SPSS</jats:styled-content>, version 15.0, while meta‐analysis was carried using <jats:styled-content style="fixed-case">MIX</jats:styled-content> 2.0 software.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>None of the <jats:italic><jats:styled-content style="fixed-case">COX</jats:styled-content>‐2</jats:italic> polymorphisms independently were associated with the risk of <jats:styled-content style="fixed-case">CP</jats:styled-content>. Meta‐analysis suggested a significant reduced risk of <jats:styled-content style="fixed-case">CP</jats:styled-content> with rs5275+8473 <jats:styled-content style="fixed-case">C</jats:styled-content> allele and rs20417 in <jats:styled-content style="fixed-case">C</jats:styled-content>hinese population.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>No association was observed in any of the studied <jats:italic><jats:styled-content style="fixed-case">COX</jats:styled-content>‐2</jats:italic> polymorphisms with <jats:styled-content style="fixed-case">CP</jats:styled-content> in <jats:styled-content style="fixed-case">N</jats:styled-content>orth <jats:styled-content style="fixed-case">I</jats:styled-content>ndia. But, the study should be replicated in larger sample size to arrive at a definitive conclusion. Meta‐analysis suggested a role of rs5275 <jats:styled-content style="fixed-case">COX</jats:styled-content>‐2 polymorphisms in susceptibility to overall <jats:styled-content style="fixed-case">CP</jats:styled-content>, and on ethnic basis, rs20417 showed reduced risk of <jats:styled-content style="fixed-case">CP</jats:styled-content> in <jats:styled-content style="fixed-case">C</jats:styled-content>hinese population.</jats:p></jats:sec>