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Medientyp:
E-Artikel
Titel:
Pediatric toxic epidermal necrolysis treated successfully with infliximab
Beteiligte:
Chafranska, Lana;
Saunte, Ditte M.;
Behrendt, Nille;
Nygaard, Ulrikka;
Christensen, Ryan J.;
Sand, Carsten;
Jemec, Gregor B.
Erschienen:
Wiley, 2019
Erschienen in:Pediatric Dermatology
Sprache:
Englisch
DOI:
10.1111/pde.13778
ISSN:
1525-1470;
0736-8046
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Successful management of toxic epidermal necrolysis (<jats:styled-content style="fixed-case">TEN</jats:styled-content>) with tumor necrosis factor‐α inhibitors has been described in adults. We present a case of a 7‐year‐old boy with infection‐associated <jats:styled-content style="fixed-case">TEN</jats:styled-content>, diagnosed by typical clinical and histopathological features, most likely caused by <jats:italic>Mycoplasma pneumoniae</jats:italic>. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Sequelae were mild, consisting of postinflammatory hyperpigmentation and dry eyes.</jats:p>