• Medientyp: E-Artikel
  • Titel: Retracted: Oral Polypodium leucomotos increases the anti‐inflammatory and melanogenic responses of the skin to different modalities of sun exposures: a pilot study
  • Beteiligte: Calzavara‐Pinton, Pier Giacomo; Rossi, Maria Teresa; Zanca, Arianna; Arisi, Mariachiara; Gonzalez, Salvador; Venturini, Marina
  • Erschienen: Wiley, 2016
  • Erschienen in: Photodermatology, Photoimmunology & Photomedicine
  • Sprache: Englisch
  • DOI: 10.1111/phpp.12209
  • ISSN: 0905-4383; 1600-0781
  • Schlagwörter: Dermatology ; Radiology, Nuclear Medicine and imaging ; Immunology ; General Medicine ; Immunology and Allergy
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  • Beschreibung: <jats:title>Summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The effects on the inflammatory and tanning responses of sunlight/<jats:styled-content style="fixed-case">UVR</jats:styled-content> of several oral antioxidants are still unknown.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>Assess intensity, time course of the inflammatory, and tanning responses to increasing dosages of solar‐simulated radiation (<jats:styled-content style="fixed-case">SSR</jats:styled-content>) at baseline and after oral supplementation of an extract of <jats:italic>Polypodium leucotomos</jats:italic> (<jats:styled-content style="fixed-case">PLE</jats:styled-content>).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Ten healthy subjects underwent phototesting with <jats:styled-content style="fixed-case">SSR</jats:styled-content> with a visual and spectrophotometrical assessment of the responses with or without daily oral supplementation of two tablets containing 240 mg of <jats:styled-content style="fixed-case">PLE</jats:styled-content> for a total of 15 days.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p><jats:italic>Polypodium leucotomos</jats:italic> supplementation induced a significant increase of the minimal erythema dose (<jats:styled-content style="fixed-case">MED</jats:styled-content>), a faster recovery of the inflammation following the delivery of super‐erythemal doses, and no significant changes of the minimal melanogenic dose (<jats:styled-content style="fixed-case">MMD</jats:styled-content>). Spectrophotometric assessment of the Δa* in test areas exposed to equally doses of <jats:styled-content style="fixed-case">SSR</jats:styled-content> did not show differences.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p><jats:italic>Polypodium leucotomos</jats:italic> supplementation increased the <jats:styled-content style="fixed-case">MED</jats:styled-content> and induced a faster recovery of the inflammation and a stronger tanning response with no changes in the melanogenic threshold.</jats:p></jats:sec>