Beschreibung:
<jats:p>Diseases of agricultural crops caused by fungi have devastating economic and health effects. Fusarium head blight (<jats:styled-content style="fixed-case">FHB</jats:styled-content>) is one of the most damaging diseases of wheat and other small grain cereals. <jats:styled-content style="fixed-case">FHB</jats:styled-content> reduces agricultural yield while also affecting food supply and safety through deposition of toxins (mycotoxins/phytotoxins). Control of <jats:styled-content style="fixed-case">FHB</jats:styled-content> growth and toxin accumulation in grains remain major challenges. While the ultimate goal in the battle against <jats:styled-content style="fixed-case">FHB</jats:styled-content> is the development of resistant wheat varieties, the actual use of fully resistant plants that preclude any need for treatment with fungicides remains out of sight. Current antifungals being applied against <jats:styled-content style="fixed-case">FHB</jats:styled-content> are generally azole‐based inhibitors. However, usage of these azole‐based fungicides is being complicated by the facts that these are active only during specific short‐lived developmental time periods, fungi are developing increased resistance to them and they are having significant environmental impacts. As such, there is a great need for more targeted, specific and effective antifungal agents to address the significant threat of <jats:styled-content style="fixed-case">FHB</jats:styled-content>. This review provides an overview of some of the more promising fungal targets that are currently being investigated for antifungal development.</jats:p>