Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Surgical aortic valve replacement (SAVR) alters the natural course of severe aortic stenosis (AS). In this study, we aimed to determine the effects of the disease on dynamic cerebral autoregulation and vasoreactivity (VR) and to assess their changes after SAVR. We recruited 23 patients diagnosed with severe AS eligible for SAVR and 15 healthy matched controls. AS patients had lower mean VR to CO<jats:sub>2</jats:sub> (<jats:italic>P</jats:italic> = 0.005) than controls, but dynamic cerebral autoregulation was preserved. Cerebral haemodynamics showed no significant change after SAVR. Patients with smaller baseline aortic valve areas presented with smaller low frequency phase changes after surgery (<jats:italic>P</jats:italic> = 0.016). Severe AS does not seem to impact dynamic cerebral autoregulation but does reduce VR to CO<jats:sub>2</jats:sub>. SAVR does not alter cerebral autoregulation nor vasoreactivity.</jats:p>