• Medientyp: E-Artikel
  • Titel: A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
  • Beteiligte: Scott, Robert A.; Freitag, Daniel F.; Li, Li; Chu, Audrey Y.; Surendran, Praveen; Young, Robin; Grarup, Niels; Stancáková, Alena; Chen, Yuning; Varga, Tibor V.; Yaghootkar, Hanieh; Luan, Jian’an; Zhao, Jing Hua; Willems, Sara M.; Wessel, Jennifer; Wang, Shuai; Maruthur, Nisa; Michailidou, Kyriaki; Pirie, Ailith; van der Lee, Sven J.; Gillson, Christopher; Al Olama, Ali Amin; Amouyel, Philippe; Arriola, Larraitz; [...]
  • Erschienen: American Association for the Advancement of Science (AAAS), 2016
  • Erschienen in: Science Translational Medicine
  • Sprache: Englisch
  • DOI: 10.1126/scitranslmed.aad3744
  • ISSN: 1946-6234; 1946-6242
  • Schlagwörter: General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>A missense variant in GLP1R associated with lower fasting glucose levels and protective against T2D is associated with lower risk of coronary heart disease, suggesting that GLP1R agonists are not associated with an unacceptable increase in cardiovascular risk.</jats:p>