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Joyce, M. Gordon; King, Hannah A. D.; Elakhal-Naouar, Ines; Ahmed, Aslaa; Peachman, Kristina K.; Macedo Cincotta, Camila; Subra, Caroline; Chen, Rita E.; Thomas, Paul V.; Chen, Wei-Hung; Sankhala, Rajeshwer S.; Hajduczki, Agnes; Martinez, Elizabeth J.; Peterson, Caroline E.; Chang, William C.; Choe, Misook; Smith, Clayton; Lee, Parker J.; Headley, Jarrett A.; Taddese, Mekdi G.; Elyard, Hanne A.; Cook, Anthony; Anderson, Alexander; McGuckin Wuertz, Kathryn; [...]

A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates

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  • Medientyp: E-Artikel
  • Titel: A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates
  • Beteiligte: Joyce, M. Gordon; King, Hannah A. D.; Elakhal-Naouar, Ines; Ahmed, Aslaa; Peachman, Kristina K.; Macedo Cincotta, Camila; Subra, Caroline; Chen, Rita E.; Thomas, Paul V.; Chen, Wei-Hung; Sankhala, Rajeshwer S.; Hajduczki, Agnes; Martinez, Elizabeth J.; Peterson, Caroline E.; Chang, William C.; Choe, Misook; Smith, Clayton; Lee, Parker J.; Headley, Jarrett A.; Taddese, Mekdi G.; Elyard, Hanne A.; Cook, Anthony; Anderson, Alexander; McGuckin Wuertz, Kathryn; [...]
  • Erschienen: American Association for the Advancement of Science (AAAS), 2022
  • Erschienen in: Science Translational Medicine
  • Sprache: Englisch
  • DOI: 10.1126/scitranslmed.abi5735
  • ISSN: 1946-6234; 1946-6242
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants stresses the continued need for next-generation vaccines that confer broad protection against coronavirus disease 2019. We developed and evaluated an adjuvanted SARS-CoV-2 spike ferritin nanoparticle (SpFN) vaccine in nonhuman primates. High-dose (50-μg) SpFN vaccine, given twice 28 days apart, induced a T helper cell 1 (T <jats:sub>H</jats:sub> 1)–biased CD4 T <jats:sub>H</jats:sub> response and elicited neutralizing antibodies against SARS-CoV-2 wild type and variants of concern, as well as against SARS-CoV-1. These potent humoral and cell-mediated immune responses translated into rapid elimination of replicating virus in the upper and lower airways and lung parenchyma of nonhuman primates after high-dose SARS-CoV-2 respiratory challenge. The immune response elicited by SpFN vaccination and resulting efficacy in nonhuman primates support the utility of SpFN as a vaccine candidate for SARS-causing betacoronaviruses. </jats:p>