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Gallus, Marco; Roll, Wolfgang; Dik, Andre; Barca, Cristina; Zinnhardt, Bastian; Hicking, Gordon; Mueller, Christoph; Naik, Venu Narayanan; Anstötz, Max; Krämer, Julia; Rolfes, Leoni; Wachsmuth, Lydia; Pitsch, Julika; van Loo, Karen M. J.; Räuber, Saskia; Okada, Hideho; Wimberley, Catriona; Strippel, Christine; Golombeck, Kristin S.; Johnen, Andreas; Kovac, Stjepana; Groß, Catharina C.; Backhaus, Philipp; Seifert, Robert; [...]

Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis

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  • Medientyp: E-Artikel
  • Titel: Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis
  • Beteiligte: Gallus, Marco; Roll, Wolfgang; Dik, Andre; Barca, Cristina; Zinnhardt, Bastian; Hicking, Gordon; Mueller, Christoph; Naik, Venu Narayanan; Anstötz, Max; Krämer, Julia; Rolfes, Leoni; Wachsmuth, Lydia; Pitsch, Julika; van Loo, Karen M. J.; Räuber, Saskia; Okada, Hideho; Wimberley, Catriona; Strippel, Christine; Golombeck, Kristin S.; Johnen, Andreas; Kovac, Stjepana; Groß, Catharina C.; Backhaus, Philipp; Seifert, Robert; [...]
  • Erschienen: American Association for the Advancement of Science (AAAS), 2023
  • Erschienen in: Science Advances
  • Sprache: Englisch
  • DOI: 10.1126/sciadv.abq7595
  • ISSN: 2375-2548
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients presents a clinical challenge, and novel noninvasive imaging biomarkers are urgently needed. Here, we demonstrate that visualization of the translocator protein (TSPO) with [ <jats:sup>18</jats:sup> F]DPA-714-PET-MRI reveals pronounced microglia activation and reactive gliosis in the hippocampus and amygdala of patients suspected with CD8 T cell ALE, which correlates with FLAIR-MRI and EEG alterations. Back-translation into a preclinical mouse model of neuronal antigen-specific CD8 T cell–mediated ALE allowed us to corroborate our preliminary clinical findings. These translational data underline the potential of [ <jats:sup>18</jats:sup> F]DPA-714-PET-MRI as a clinical molecular imaging method for the direct assessment of innate immunity in CD8 T cell–mediated ALE. </jats:p>
  • Zugangsstatus: Freier Zugang