Chen, Chien-Chang;
Lamping, Kathryn G.;
Nuno, Daniel W.;
Barresi, Rita;
Prouty, Sally J.;
Lavoie, Julie L.;
Cribbs, Leanne L.;
England, Sarah K.;
Sigmund, Curt D.;
Weiss, Robert M.;
Williamson, Roger A.;
Hill, Joseph A.;
Campbell, Kevin P.
Abnormal Coronary Function in Mice Deficient in α 1H T-type Ca 2+ Channels
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Medientyp:
E-Artikel
Titel:
Abnormal Coronary Function in Mice Deficient in α 1H T-type Ca 2+ Channels
Beteiligte:
Chen, Chien-Chang;
Lamping, Kathryn G.;
Nuno, Daniel W.;
Barresi, Rita;
Prouty, Sally J.;
Lavoie, Julie L.;
Cribbs, Leanne L.;
England, Sarah K.;
Sigmund, Curt D.;
Weiss, Robert M.;
Williamson, Roger A.;
Hill, Joseph A.;
Campbell, Kevin P.
Erschienen:
American Association for the Advancement of Science (AAAS), 2003
Erschienen in:
Science, 302 (2003) 5649, Seite 1416-1418
Sprache:
Englisch
DOI:
10.1126/science.1089268
ISSN:
0036-8075;
1095-9203
Entstehung:
Anmerkungen:
Beschreibung:
Calcium ion (Ca 2+ ) influx through voltage-gated Ca 2+ channels is important for the regulation of vascular tone. Activation of L-type Ca 2+ channels initiates muscle contraction; however, the role of T-type Ca 2+ channels (T-channels) is not clear. We show that mice deficient in the α 1H T-type Ca 2+ channel (α 1 3.2-null) have constitutively constricted coronary arterioles and focal myocardial fibrosis. Coronary arteries isolated from α 1 3.2-null arteries showed normal contractile responses, but reduced relaxation in response to acetylcholine and nitroprusside. Furthermore, acute blockade of T-channels with Ni 2+ prevented relaxation of wild-type coronary arteries. Thus, Ca 2+ influx through α 1H T-type Ca 2+ channels is essential for normal relaxation of coronary arteries.