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Nene, Vishvanath; Wortman, Jennifer R.; Lawson, Daniel; Haas, Brian; Kodira, Chinnappa; Tu, Zhijian (Jake); Loftus, Brendan; Xi, Zhiyong; Megy, Karyn; Grabherr, Manfred; Ren, Quinghu; Zdobnov, Evgeny M.; Lobo, Neil F.; Campbell, Kathryn S.; Brown, Susan E.; Bonaldo, Maria F.; Zhu, Jingsong; Sinkins, Steven P.; Hogenkamp, David G.; Amedeo, Paolo; Arensburger, Peter; Atkinson, Peter W.; Bidwell, Shelby; Biedler, Jim; [...]

Genome Sequence of Aedes aegypti , a Major Arbovirus Vector

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  • Medientyp: E-Artikel
  • Titel: Genome Sequence of Aedes aegypti , a Major Arbovirus Vector
  • Beteiligte: Nene, Vishvanath; Wortman, Jennifer R.; Lawson, Daniel; Haas, Brian; Kodira, Chinnappa; Tu, Zhijian (Jake); Loftus, Brendan; Xi, Zhiyong; Megy, Karyn; Grabherr, Manfred; Ren, Quinghu; Zdobnov, Evgeny M.; Lobo, Neil F.; Campbell, Kathryn S.; Brown, Susan E.; Bonaldo, Maria F.; Zhu, Jingsong; Sinkins, Steven P.; Hogenkamp, David G.; Amedeo, Paolo; Arensburger, Peter; Atkinson, Peter W.; Bidwell, Shelby; Biedler, Jim; [...]
  • Erschienen: American Association for the Advancement of Science (AAAS), 2007
  • Erschienen in: Science, 316 (2007) 5832, Seite 1718-1723
  • Sprache: Englisch
  • DOI: 10.1126/science.1138878
  • ISSN: 0036-8075; 1095-9203
  • Entstehung:
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  • Beschreibung: <jats:p> We present a draft sequence of the genome of <jats:italic>Aedes aegypti</jats:italic> , the primary vector for yellow fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the genome of the malaria vector <jats:italic>Anopheles gambiae</jats:italic> . Nearly 50% of the <jats:italic>Ae. aegypti</jats:italic> genome consists of transposable elements. These contribute to a factor of ∼4 to 6 increase in average gene length and in sizes of intergenic regions relative to <jats:italic>An. gambiae</jats:italic> and <jats:italic>Drosophila melanogaster</jats:italic> . Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of ∼2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to <jats:italic>An. gambiae</jats:italic> suggests that members of these protein families underpin some of the biological differences between the two mosquito species. </jats:p>