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Medientyp:
E-Artikel
Titel:
Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”
Beteiligte:
Veeraraghavalu, Karthikeyan;
Zhang, Can;
Miller, Sean;
Hefendehl, Jasmin K.;
Rajapaksha, Tharinda W.;
Ulrich, Jason;
Jucker, Mathias;
Holtzman, David M.;
Tanzi, Rudolph E.;
Vassar, Robert;
Sisodia, Sangram S.
Erschienen:
American Association for the Advancement of Science (AAAS), 2013
Erschienen in:
Science, 340 (2013) 6135, Seite 924-924
Sprache:
Englisch
DOI:
10.1126/science.1235505
ISSN:
0036-8075;
1095-9203
Entstehung:
Anmerkungen:
Beschreibung:
Cramer et al . (Reports, 23 March 2012, p. 1503; published online 9 February 2012) reported that bexarotene rapidly reduces β-amyloid (Aβ) levels and plaque burden in two mouse models of Aβ deposition in Alzheimer’s disease (AD). We now report that, although bexarotene reduces soluble Aβ 40 levels in one of the mouse models, the drug has no impact on plaque burden in three strains that exhibit Aβ amyloidosis.