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Medientyp:
E-Artikel
Titel:
Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert
Beteiligte:
Ariotti, Silvia;
Hogenbirk, Marc A.;
Dijkgraaf, Feline E.;
Visser, Lindy L.;
Hoekstra, Mirjam E.;
Song, Ji-Ying;
Jacobs, Heinz;
Haanen, John B.;
Schumacher, Ton N.
Erschienen:
American Association for the Advancement of Science (AAAS), 2014
Erschienen in:Science
Sprache:
Englisch
DOI:
10.1126/science.1254803
ISSN:
0036-8075;
1095-9203
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Resident memory T cells sound the alarm</jats:title>
<jats:p>
Immunological memory protects against reinfection. Resident memory T cells (T
<jats:sub>RM</jats:sub>
) are long-lived and remain in the tissues where they first encountered a pathogen (see the Perspective by Carbone and Gebhardt). Schenkel
<jats:italic>et al.</jats:italic>
and Ariotti
<jats:italic>et al.</jats:italic>
found that CD8
<jats:sup>+</jats:sup>
T
<jats:sub>RM</jats:sub>
cells act like first responders in the female reproductive tissue or the skin of mice upon antigen reencounter. By secreting inflammatory proteins, T
<jats:sub>RM</jats:sub>
cells rapidly activated local immune cells to respond, so much so that they protected against infection with an unrelated pathogen. Iijima and Iwasaki found that CD4
<jats:sup>+</jats:sup>
T
<jats:sub>RM</jats:sub>
cells protected mice against reinfection with intravaginal herpes simplex virus 2.
</jats:p>
<jats:p>
<jats:italic>Science</jats:italic>
, this issue p.
<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6205" page="98" related-article-type="in-this-issue" vol="346" xlink:href="10.1126/science.1254536">98</jats:related-article>
, p.
<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6205" page="101" related-article-type="in-this-issue" vol="346" xlink:href="10.1126/science.1254803">101</jats:related-article>
, p.
<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6205" page="93" related-article-type="in-this-issue" vol="346" xlink:href="10.1126/science.1257530">93</jats:related-article>
; see also p.
<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6205" page="40" related-article-type="in-this-issue" vol="346" xlink:href="10.1126/science.1259925">40</jats:related-article>
</jats:p>