Erschienen:
American Association for the Advancement of Science (AAAS), 2015
Erschienen in:Science
Sprache:
Englisch
DOI:
10.1126/science.1260668
ISSN:
0036-8075;
1095-9203
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>For T cells, variety is the spice of life</jats:title>
<jats:p>
CD4
<jats:sup>+</jats:sup>
helper T cells come in a variety of flavors. This allows them to respond in a manner that is tailored to the pathogen they encounter. Becattini
<jats:italic>et al.</jats:italic>
wondered whether multiple “flavors” of human CD4
<jats:sup>+</jats:sup>
T cells respond to specific stimuli or if just one flavor dominates. To find out, they stimulated human memory CD4
<jats:sup>+</jats:sup>
T cells with a fungus, a bacteria, or a vaccine antigen. Multiple helper cell subsets participated in each response. T cell receptor sequencing revealed that in some cases, T cells with the same specificity acquired different helper cell fates. Thus, there is more heterogeneity in human T cell responses than previously appreciated.
</jats:p>
<jats:p>
<jats:italic>Science</jats:italic>
, this issue p.
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