Beschreibung:
<jats:p>
In a study aimed at developing a vaccine against the asexual blood stages of
<jats:italic>Plasmodium falciparum</jats:italic>
, two T cell epitopes were identified within a nonpolymorphic region of gp190 of
<jats:italic>Plasmodium falciparum</jats:italic>
merozoites. The two epitopes, which were revealed by deletion analysis, stimulated human T cell clones. Peptides containing sequences of the epitopes stimulated the cloned T cells and peripheral blood mononuclear cells (PBMC) from malaria-infected individuals. Moreover, the T cell clones responded to 11 different
<jats:italic>Plasmodium falciparum</jats:italic>
isolates in culture, showing that the epitopes are recognized in native parasites.
</jats:p>